Lecture Notes CEM352 SS 2026
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Chapter 14 Notes: Monday and Wednesday (January 12 and January 14, 2026) ------------------------------------ Notes: Friday, January 16, 2026 ------------------------------------ Conjugated pi-system MO diagrams using shorthand notation (Click Here)
Notes: ../01212026_Wednesday.pdf, January 21, 2026
Notes Friday, January 23, 2026 (Diels-Alder Stereoisomerism and Endo Exo preference)
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Chapter 15 · Notes: Friday, January 23, 2026
In-Class Handout (Friday, January 23, 2026) ------------------------------------
· Notes: Monday, January 26, 2026 (Spectroscopic properties – IR, NMR, uv - of Aromatic Compounds, Aromaticity, Anti-Aromatic, Non-Aromatic, Huckel’s Rule) (Audio/Video accompaniment) ------------------------------------
· Notes: Wednesday, January 28, 2026 (Audio/Video accompaniment)
Chapter 15/16 · Notes: Monday, February 02, 2026 (Audio/Video accompaniment)
Chapter 16 · Notes: Wednesday, February 04, 2026 (Audio/Video accompaniment) ------------------------------------
· Notes: Friday, February 06, 2026 (No Audio/Video accompaniment) ------------------------------------
Chapter 16/17 · Notes: Monday, February 09, 2026 (No Audio/Video accompaniment)
Chapter 17 · Notes: Wednesday, February 11, 2026 (Audio/Video Accompaniment)
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· Notes: Monday, February 16, 2026 (Audio/Video Accompaniment) ------------------------------------
· Notes: Wednesday, February 18, 2026 (Audio/Video Accompaniment) ------------------------------------
· Notes: Friday, February 20, 2026 (Audio/Video accompaniment) ----------------------------------- Chapter 18 · Notes: Monday, February 23, 2026 (Audio/Video accompaniment)
· Notes: Wednesday, February 25, 2026 (Audio/Video accompaniment) Wednesday In-Class Handout (not available)
· Notes: Monday, March 09, 2026 (NO Audio/Video accompaniment)
· Notes: Wednesday, March 11, 2026 (Audio/Video accompaniment) - coming
· Notes: Friday, March 13, 2026 -------------------------- Chapter 18/19 · Notes: Monday, March 16, 2026
· Notes: Wednesday, March 18, 2026
· Notes: Friday, March 20, 2026 (Audio/Video accompaniment) – coming soon
· Notes: Monday, March 23, 2026 (Audio/Video accompaniment) - None
------------------------- Chapter 21 Online videos Amine from Cyanide and Reductions Amines to Nitrosamines using NaNO2 (sodium nitrite, HCl, and 1° or 2° amines) (Nitrosamines impurities in drug manufacturing)
· Notes: Monday, March 30, 2026 (Audio/Video accompaniment)-none Monday In-Class Handout (none) Student Research Presentation SW
· Notes: Wednesday, April 01, 2026 (Audio/Video accompaniment)-none Wednesday In-Class Handout (none) Student Research Presentation AL
· Notes: Friday, April 03, 2026 (Audio/Video accompaniment)-none Wednesday In-Class Handout (none)
------------------------- Chapter 22 Online videos – press pause frequently to understand the logic Nucleophilic (SN2/SN1) Reactions at Benzylic Carbons (Video 1) (Video 2, benzylic discussion starts at 4:50 min) Birch Reduction (Video 1, Video 2 – Aryl rings with substituents) H2 Reduction – this is also used with benzyl alcohol or benzyl esters Oxidation of Benzylic Carbon to CO2H or aldehyde/ketone Video 1, Video 2) SNAr (Nucleophilic Aromatic Substitution Reactions) – Notice different mechanisms for when EWGs and no EWGs are on the ring Cope Rearrangement (identify ‘allyl’/’allyl’ functional groups) Claisen Rearrangement (identify “enol”/“allyl” functional groups) Hydroquinone to Quinone Oxidation Sandmeyer Reaction (Reaction examples) (updated on April 17, 2026)
· Notes: Monday, April 06, 2026 (updated on April 17, 2026)
· Notes: Wednesday, April 08, 2026 Wednesday In-Class Handout – none
· Notes: Friday, April 10, 2026 (updated on April 17, 2026)
------------------------- Chapter 23 Online videos Claisen Condensations via Ester Enolates Dieckmann Condensation (Cyclized Claisen Condensation) Reactions of β-Dicarbonyl Compounds – Notice the increased acidity of the α-carbon hydrogens of a dicarbonyl compound vs the α-carbon hydrogens of a monocarbonyl. One mistake at 4:25. The product should be a carboxylate, not a carboxylic acid. If you heat the carboxylate without adding more base, you will decarboxylate. Use of a Thiazolium Salt to Condense Two Aldehydes and Form an α-Hydroxyketone. Can you find the errors in the video? KMnO4 Oxidation: Strange Mechanism that is not consistent when there’s a butyl side chain or 1-benzylic H Alternative mechanism to consider
· Notes: Monday, April 13, 2026 (Version 2 of Monday’s lecture notes from Chapter 23 Summary) Monday In-Class Handout - none Student Research Presentation AM
· Notes: Wednesday, April 15, 2026 (updated on April 20, 2026: Claisen in SN2, Retrosynthesis analysis to make β-keto esters, α-Carboxylate decarboxylation, Robinson Annulation after 1,4-Michael Addition between Enolate and a Carbonyl with Proper Chain Length to do an Annulation) Wednesday In-Class Handout
· Notes: Friday, April 17, 2026 Friday Problems Done In-Class Friday Handout
KMnO4 Oxidation: Strange Mechanism that is not consistent when there’s a butyl side chain or 1-benzylic H. Be careful when watching YouTube videos for instruction Alternative mechanism to consider
------------------------- Chapter 24
· Notes: Monday, April 20, 2026 Monday Handout
· Notes: Wednesday, April 22, 2026
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CEM 351 Review Topics (we cannot jettison our CEM 351 knowledge) |
