Lu, X.; Huang, X.* “Design and Syntheses of Hyaluronan Oligosaccharide Conjugates as Inhibitors of CD44-Hyaluronan Binding” Glycoconjugate J. 2015, 32,549-556(special issue dedicated to Chemical Glycobiology).

Zhou, W.; Hsieh, P.-H., Xu, Y.; Huang, X., Liu, J.* “Design and Synthesis of Active Heparan Sulfate-based Probes” Chem. Commun. 2015, 51, 11019-11021.

Qin, Q.; Yin, Z.; Bentley, P.; Huang, X.* Carbohydrate Antigen Delivery by Water Soluble Copolymers as Potential Anti-cancer Vaccines, Med. Chem. Commun. 2014, 5, 1126-1129 (This article was highlighted as the inside cover of the issue)

Yoshida, K.; Yang, B.; Yang, W.; Zhang, Z.; Zhang, J. Huang, X.* Chemical Synthesis of Human Syndecan-3 Glycopeptides Bearing Two Heparan Sulfate Glycan Chains, Angew. Chem. Int. Ed. 2014, 53, 9051-9058

El-dakdouki, M; Xia, J; Zhu, D. C.; Kavunja, H.; Grieshaber, J.; O'Reilly, S.; McCormick, J. J.; Huang, X.* Assessing the in Vivo Efficacy of Doxorubicin Loaded Hyaluronan Nanoparticles, ACS Appl. Mater. Interface, 2014, 6, 697–705

El-dakdouki, M.; El-boubbou, K.; Kamat, M.; Huang, R.; Abela, G.; Zhu, D. C.*; Huang, X.* CD44 Targeting Magnetic Glyconanoparticles for Atherosclerotic Plaque Imaging, Pharm Res. 2014, 31, 1426-1437 (Highlighted as front cover of the issue)

El-dakdouki, M.; El-boubbou, K.; Xia, J.; Kavunja, H.; Huang, X.* Methods for Magnetic Nanoparticle Synthesis and Functionalization Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications Editor: Ravin Rarain, John Wiley & Sons, 2014, pp 281-314

2013

Wasonga, G.; Tatara, Y.; Kakizaki, I.; Huang, X.* Synthesis of N-Acetyl Glucosamine Analogs as Inhibitors for Hyaluronan Biosynthesis, J. Carbohydr. Chem. 2013, 32, 392-409

Huang, X.; Vocadlo, D. Reports from the Award Symposia Hosted by the American Chemical Society, Division of Carbohydrate Chemistry at the 245th American Chemical Society National Meeting, ACS Chem. Biol. 2013, 8, 1361-1365

Yin, J.; Comellas-Aragones, M.; Chowdhury, S.; Bentley, P.; Kaczanowska, K.; BenMohamed, L.; Gildersleeve, J. C.; Finn, M.G.; Huang, X.* Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids, ACS Chem. Biol., 2013, 8, 1253-1262
This work has been highlighted by Chemical & Engineering News as well as in the June 2013 POD cast from ACS Chemical Biology

El-dakdouki, M.; Puré, E.; Huang, X.* Development of Drug Loaded Nanoparticles for Tumor Targeting. Part 2: Enhancement of Tumor Penetration Through Receptor Mediated Transcytosis in 3D Tumor Models, Nanoscale, 2013, 5, 3904-3911

El-dakdouki, M.; Puré, E.; Huang, X.* Development of Drug Loaded Nanoparticles for Tumor Targeting. Part 1: Synthesis, Characterization, and Biological Evaluation in 2D Cell Cultures, Nanoscale, 2013, 5, 3895-3903

Kouyoumdjian, H.; Zhu, D. C.; El-Dakdouki, M. H.; Lorenz, K.; Chen, J.; Li, W.; Huang, X.* Glyconanoparticle Aided Detection of β-Amyloid by Magnetic Resonance Imaging and Attenuation of β-Amyloid Induced Cytotoxicity, ACS Chem. Neurosci., 2013, 4, 575−584

2012

Yang, B.; Yoshida, K.; Yin, Z.; Dai, H.; Kavunja, H.; El-Dakdouki, M. H.; Sungsuwan, S.; Dulaney, S. B.; Huang, X.* Chemical Synthesis of Homogeneous Syndecan-1 Heparan Sulfate Glycopeptide, Angew. Chem. Int. Ed., 2012, 51, 10185-10189

Yin, Z.; Nguyen, H. G.; Chowdhury, S.; Bentley, P.; Bruckman, M. A.; Miermont, A.; Gildersleeve, J. C.; Wang, Q.; Huang, X.* Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens, Bioconjugate Chem., 2012, 23, 1694-1703. NIHMSID: 396464

Huang, X. Foreword, J. Carbohydr. Chem., 2012, 31, 253-254 Foreword to the Special Issue Dedicated to the 7th Midwest Carbohydrate and Glycobiology Symposium

Sheng, J.; Xu, Y.; Dulaney, S. B.; Huang, X.; Liu, J.* Uncovering a Biphasic Catalytic Mode of C5-epimerase in Heparan Sulfate Biosynthesis, J. Biol. Chem., 2012, 287, 20996-21002

Xu. Y.; Wang, Z.; Liu, R.; Bridges, A. S.; Huang, X.; Liu, J.* Directing the Biological Activities of Heparan Sulfate Oligosaccharides Using a Chemoenzymatic Approach, Glycobiology, 2012, 22, 96-106

Sun, B.; Yang, B.; Huang, X.* Total Synthesis of the Aminopropyl Functionalized Ganglioside GM1, Sci. China Chem., 2012, 55, 31-35

Li, H.; El-dakdouki, M.H.; Zhu, D. C.; Abela, G. S.; Huang, X.* Synthesis of b-cyclodextrin Conjugated Superparamagnetic Iron Oxide Nanoparticles for Detection of Cholesterol Crystals, Chem. Commun., 2012, 48, 3385-3387 (This article was highlighted as the back cover of the issue)

El-dakdouki, M.H.; Zhu, D. C.; El-Boubbou, K.; Kamat, M.; Chen, J.; Li, W.; Huang, X.* Development of Multifunctional Hyaluronic Acid Coated Nanoparticles: Targeted Imaging and Drug Delivery to Cancer Cells in vitro, Biomacromolecules, 2012, 13, 1144-1151

Dulaney, S. B.; Huang, X.* Recent Strategies in Heparin/heparan Sulfate Oligosaccharide Synthesis: 2000 – present, Adv. Carbohydr. Chem. Biochem., 2012, 67, 95-136 (invited review)

Yin, Z.; Huang, X.* Recent Development in Carbohydrate Based Anti-cancer Vaccines, J. Carbohydr. Chem., 2012, 31, 143-186

2011

El-dakdouki, M.H.; El-Boubbou, K.; Zhu, D. C.; Huang, X.* A Simple Method for the Synthesis of Hyaluronic Acid Coated Magnetic Nanoparticles for Highly Efficient Cell Labeling and in vivo Imaging, RSC Adv., 2011, 1, 1449-1452

El-dakdouki, M.H.; Huang, X.* Biological Applications of Hyaluronic Acid Functionalized Nanomaterials, in Glyco-Nanotechnology as a Bridge to New Medicines, ACS symposium series, Editors: Huang, X.; Barchi, J. 2011, 181-213

Tiruchinapally, G.; Yin, Z.; El-dakdouki, M.H.; Wang, Z.; Huang, X.* Divergent Heparin Oligosaccharide Synthesis with Pre-installed Sulfate Esters, Chem. Eur. J., 2011, 17, 10106 – 10112

El-boubbou, K.; Huang, X.* Glyco-Nanomaterials: Translating Insights from the “Sugar-code” to Biomedical Applications, Curr. Med. Chem. , 2011, 18, 2060-2078

Deng, C. X.; Huang, X.* Improved Outcome of Targeted Delivery of Chemotherapy Drug to the Brain using a Combined Strategy of Ultrasound, Magnetic Targeting, and Drug Loaded Nanoparticles, Therapeutic Delivery , 2011, 2, 137–141

Li, X.; Zhou, H.; Yang, L.; Du, G.; Pai-Panandiker, A. S.; Huang, X.; Yan, B.* Enhancement of Cell Recognition in vitro by Dual-ligand Cancer Targeting Gold Nanoparticles, Biomaterials, 2011, 232, 2540-2545

Wasonga, G.; Zeng, Y.; Huang, X.* Pre-activation Based Stereoselective Glycosylations: Stereochemical Control by Additives and Solvent, Sci. China Chem., 2011, 54, 1, 66-73

2010

Kamat, M.; El-Boubbou, K.; Zhu, D.; Lansdell, T.; Lu, X.; Li, W.; Huang, X.* Hyaluronic Acid Immobilized Magnetic Nanoparticles for Active Targeting and Imaging of Macrophages, Bioconjugate Chem., 2010, 21, 11, 2128–2135

Wang, Z.; Xu, Y.; Yang, B.; Tiruchinapally, G.; Sun, B.; Liu, R.; Dulaney, S.; Liu, J.; Huang, X.* Pre-activation-Based One-pot Combinatorial Synthesis of Heparin-like Hexasaccharides for the Analysis of Heparin–Protein Interactions, Chem. Eur. J., 2010, 16, 28, 8365-8375. (This article was rated by the reviewers as VIP publication)

El-Boubbou, K.; Zhu, D.; Vasileiou, C.; Borhan, B.; Prosperi, D.; Li, W.; Huang, X.* Magnetic Magnetic Glyco-Nanoparticles: A Tool To Detect, Differentiate, and Unlock the Glyco-Codes of Cancer via Magnetic Resonance Imaging, J. Am. Chem. Soc., 2010, 132, 12, 4490-4499.

Yang, B.; Jing, Y.; Huang, X.* Fluorous Assisted One-pot Oligosaccharide Synthesis. Eur. J. Org. Chem., 2010, 7, 1290–1298.

Wang, Y.; El-Boubbou, K.; Kouyoumdjian, H.; Sun, B.; Huang, X.; Zeng, X.* Lipoic Acid Carbohydrate Conjugates, a New Class of Agents for Controlling Nonspecific Adsorption of Blood Serum at Bio-interfaces for Biosensor and Biomedical Applications, Langmuir, 2010, 26, 4119-4125.

2009

Lu, X.; Kamat, M. N.; Huang, L.; Huang, X.* Chemical Synthesis of a Hyaluronic Acid Decasaccharide, J. Org. Chem., 2009, 74, 7608-7617 (JOC Featured article)

Li, X.; Huang, L.; Hu, X.; Huang, X.* Thio-arylglycosides with Various Aglycon Para-Substituents, a Useful Tool for Mechanistic Investigation of Chemical Glycosylations, Org. Biomol. Chem., 2009, 7, 117-127.

2008

Zeng, Y.; Wang, Z.; Whitfield, D., Huang, X.* Installation of Electron Donating Protective Groups, a Strategy for Glycosylating Unreactive Thioglycosyl Acceptors using the Pre-activation Based Glycosylation Strategy, J. Org. Chem., 2008, 73, 7952-7962.

Wang, Z.; Huang, X.* p-Toluenesulfenyl Chloride Electronic Encyclopedia of Reagents in Organic Synthesis, 2008.

Sun, B.; Srivinasan, B.; Huang, X.* Pre-activation Based One-pot Synthesis of an α-(2,3)-Sialylated Core-Fucosylated Complex Type Bi-antennary N-Glycan Dodecasaccharide, Chem. Eur. J., 2008, 14, 7072-7081

Wang, Z.; Gilbert, M.; Eguchi, H.; Yu, H.; Cheng, J.; Muthana, S.; Zhou, L.; Wang, P. G.; Chen, X.; Huang, X.* Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4, Adv. Synth. Catal., 2008, 350, 1717-1728.

Miermont, A.; Barnhill, H.; Strable, E.; Lu, X.; Wall, K. A.; Wang, Q.; Finn, M. G.; Huang, X.* Cowpea Mosaic Virus Capsid, a Promising Carrier towards the Development of Carbohydrate Based Anti-tumor Vaccines, Chem. Eur. J., 2008, 14, 4939-4947.

Huang, L.; Lu, X.; Huang, X.* Chemical Syntheses of Hyaluronic Acid Oligosaccharides, in Chemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, ACS symposium series, 2008.

Srinivasan, B.; Huang, X.* Functionalization of Magnetic Nanoparticles with Organic Molecules: Loading Level Determination and Evaluation of Linker Length Effect on Immobilization, Chirality , 2008, 20, 265-277. (Special issue dedicated to Prof. Nina Berova)

2007

El-Boubbou, K.; Gruden, C.; Huang, X.* Magnetic Glyco-nanoparticles: A Unique Tool for Rapid Pathogen Detection, De-contamination and Strain Differentiation, J. Am. Chem. Soc., 2007, 129, 13392-13393.

Miermont, A.; Zeng, Y.; Jing, Y.; Ye, X.-S.; Huang, X.* Syntheses of LewisX and Dimeric LewisX: Construction of Branched Oligosaccharides by a Combination of Pre-activation and Reactivity Based Chemoselective One-Pot Glycosylations, J. Org. Chem. , 2007, 72, 8958-8961.

Teumelsan, N.; Huang, X.* Synthesis of Branched Oligomannans and an Unusual Stereochemical Observation, J. Org. Chem. , 2007, 72, 8976-8979.

Wang, Z.; Zhou, L.; El-boubbou, K.; Ye, X.-S.; Huang, X.* Four Component One-Pot Synthesis of the Tumor-Associated Carbohydrate Antigen Globo-H Based on Preactivation of Thioglycoside Donors. J. Org. Chem. , 2007, 72, 6409-6420.

Wang, Z.; Huang, X.* Strategies in Oligosaccharide Synthesis in Comprehensive Glycoscience. From Chemistry to Systems Biology 2007, Editor: J. P. Kamerling, Elsevier, p379-413.

Huang, L.; Huang, X.* Highly Efficient Syntheses of Hyaluronan Oligosaccharides, Chem. Eur. J. 2007, 13, 529-540.

2006

Wang, C.; Wang, H.; Huang, X.; Zhang, L.-H.; Ye, X.-S.* Benzenesulfinyl Morpholine: A New Promoter for One-Pot Oligosaccharide Synthesis Using Thioglycosides by Pre-Activation Strategy, Synlett 2006, 2846-2850.

Huang, L.; Teumelsan, N.; Huang, X.* A Facile Method for Oxidation of Primary Alcohols to Carboxylic Acids and Its Application in Glycosaminoglycan Syntheses, Chem. Eur. J. 2006, 12, 5246-5252.

Huang, L.; Wang, Z.; Li, X.; Huang, X.* Iterative One-Pot Synthesis of Chitotetraose, Carbohydr. Res. 2006, 341, 1669-1679.

2005

Huang, L.; Huang, X.* Methyl triflate, Electronic Encyclopedia of Reagents in Organic Synthesis, 2005.

2004

Wang, Y.; Huang, X.; Zhang, L.-H.; Ye, X.-S.* A Four-Component One-Pot Synthesis of a-Gal Pentasaccharide Org. Lett. 2004, 6, 4415-4417.

Huang, X. Mercuric Bromide, Electronic Encyclopedia of Reagents in Organic Synthesis, 2004, RN00383.

Huang, X.*; Huang, L.; Wang, H.; Ye, X.-S. Iterative One-Pot Oligosaccharide Synthesis, Angew. Chem. Int. Ed. 2004, 5221-5224.

Huang, L.; Wang, Z.; Huang, X.* One-pot Oligosaccharide Synthesis: Reactivity Tuning by Post-synthetic Modification of Aglycon, Chem. Commun. 2004, 1960-1961.

Jing, Y.; Huang, X.* Fluorous Thiols in Oligosaccharide Synthesis, Tetrahedron Lett. 2004, 45, 4615-4618

1995-2003

Journal articles (Corresponding authors are highlighted with a *. Peer reviewed articles are designated with a p after the full citation.)

From Work Conducted During Undergraduate, Graduate and Postdoctoral Periods

1. Li, J.*; Zhang, J.; Huang, X.; Du, S.; Wu, X. “Crystal Structure of An Unusual Four Coordinated Copper (II) Complex Containing 1, 10-Phenanthroline and Salicyclic Acid” Cryst. Res. Technol. 1995, 30, 211-116.p

2. Li, J.*; Xu, M.; Huang, X.; Zhang, Y. “Spectroscopic and Structural Properties of Dichloro-(L-histidine) Copper (II) Crystal” Spec. Lett. 1995, 28, 111-118.p

3. Nakanishi, K.*; Huang, X.; Jiang, H.; Liu, Y.; Fang, K.; Huang, D.; Choi. S.-K.; Katz, E.; Eldefrawi, M.E. “Structure/binding Relation of Philanthotoxins from Nicotinic Acetylcholine Receptor Binding Assay” Bioorg. Med. Chem. 1997, 5, 1969-1988.p

4. Huang, X.; Rickman, B.; Borhan, B.; Bevora, N.; Nakanishi, K.* “Zinc Porphyrin Tweezer in Host-guest Complexation: Determination of Absolute Configurations of Diamines, Amino Acids, and Amino Alcohols by Circular Dichroism” J. Am. Chem. Soc. 1998, 120, 6185-6186.p

5. Huang, X.; Borhan, B.; Berova, N.; Nakanishi, K.* “UV-vis Spectral Changes in the Binding of Acyclic Diamines with a Zinc Porphyrin Tweezer” J. Ind. Chem. Soc. 1998, 75, 725-728. (Special issue for Prof. Sukh Dev’s 75th birthday)p

6. Berova, N.; Borhan, B.; Dong, J.-G.; Guo, J.; Huang, X.; Karnaukhova, E.; Kawamura, A.; Lou, J.; Matile, S.; Nakanishi, K.*; Rickman, B.; Su, J.; Tan, Q.; Zanze, I. “Solving Challenging Bioorganic Problems by Exciton Coupled CD” Pure App. Chem. 1998, 70, 377-383.p

7. Huang, X.; Borhan, B.; Matile, S.; Nakanishi, K.* “Spectroscopic Studies of PhTX Facilitated Cation Movement Across Membranes” Bioorg. Med. Chem. 1999, 7, 811-814. (Special issue in memory of Sir. Derek H. Barton)p

8. Jiang, H.; Huang, X.; Nakanishi, K.*; Berova, N.* “Nanogram Scale Absolute Configurational Assignment of Ceramides by Circular Dichroism” Tetrahedron Lett. 1999, 40, 7645-7649.p

9. Huang, X.; Nakanishi, K.*; Berova, N.* “Porphyrins and Metalloporphyrins: Versatile Circular Dichroic Reporter Groups for Structural Studies” Chirality 2000, 12, 237-255.p

10. Huang, X.; Borhan, B.; Rickman, B. H.; Berova, N.; Nakanishi, K.* “Zinc Porphyrin Tweezer in Host-Guest Complexation: Determination of Absolute Configurations of Primary Monoamines by Circular Dichroism” Chem.-Eur. J. 2000, 6, 216-224.p

11. Tsai, C.-Y.; Huang, X.; Wong, C.-H.* “Design and Synthesis of Cyclic Sialyl Lewis X Mimetics: a Remarkable Enhancement of Inhibition by Pre-organizing All Essential Functional Groups” Tetrahedron Lett. 2000, 41, 9499-9503.p

12. Huang, X.; Witte, K. L.; Bergbreiter, D. E.; Wong, C.-H.* “Homogenous Enzymatic Synthesis Using a Thermo-Responsive Water-Soluble Polymer Support” Adv. Synth. Catal. 2001, 1, 675-681.p

13. Kurtán, T.; Nesnas, N.; Li, Y.-Q.; Huang, X.; Nakanishi, K.*; Berova, N.* "Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 1. Chiroptical Protocol for Absolute Configurational Assignments of Monoalcohols and Primary Monoamines" J. Am. Chem. Soc. 2001, 123, 5962-5973.p

14. Kozlov, I.A.; Mao, S.; Xu, Y.; Huang, X.; Lee, L.V.; Sears, P.S.; Gao, C.; Coyle, A.R.; Janda, K.D.; Wong, C-H.* "Synthesis of Solid Supported Mirror-Image Sugars: A Novel Method for Selecting Receptors for Cellular Surface Carbohydrates" ChemBioChem. 2001, 2, 741-746.p

15. Ye, X.-S.; Huang, X.; Wong, C.-H.* “Conversion of the Carboxy Group of Sialic Acid Donors to a Protected Hydroxymethyl Group Yields an Efficient Reagent for the Synthesis of the Unnatural -linkage” Chem. Commun. 2001, 974-975.p

16. Solladié-Cavallo, A.*; Marsol, C.; Pescitelli, G.; Di Bari, L.; Salvadori, P.; Huang, X.; Fujioka, N.; Berova, N.; Cao, X.; Freedman, T. B.; Nafié, L. A. “(R)-(+)- and (S)-(-)-1-(9-Phenanthryl)ethylamine: Assignment of Absolute Configuration by CD Tweezer and VCD Methods, and Difficulties Encountered with the CD Exciton Chirality Method” Eur. J. Org. Chem. 2002, 1788-1796.p

17. Huang, X.; Fujioka, N.; Pescitelli, G.; Koehn, F. E.; Williamson, R. T.; Nakanishi, K.*; Berova, N.* “Absolute Configurational Assignments of Secondary Amines by CD-Sensitive Dimeric Zinc Porphyrin Host” J. Am. Chem. Soc. 2002, 124, 10320-10335.p

18. Proni, G.; Pescitelli, G.; Huang, X.; Nakanishi, K.*; Berova, N.* “Configurational Assignment of -chiral Carboxylic Acids by Complexation to Dimeric Zn-porphyrin: Host/Guest Structure, Chiral Recognition and Circular Dichroism” Chem. Commun. 2002, 1590-1591.p

19. Zhang, Z.; Niikura, K.; Huang, X.; Wong, C.-H.* “A Strategy for the One-pot Synthesis of Sialylated Oligosaccharides” Can. J. Chem. 2002, 80, 1051-1054.p

20. Proni, G.; Pescitelli, G.; Huang, X.; Nakanishi, K.*; Berova, N.* “Magnesium Tetraaryl-porphyrin Tweezer: a Sensitive Host for Recognition of -chiral Carboxylic Acids” J. Am. Chem. Soc. 2003, 125, 12914-12927.p

21. Balaban, T. S.; Berova, N.; Drain, C. M.; Hauschild, R.; Huang, X.; Kalt, H.; Lebedkin, S.; Lehn, J.-L.; Nifaitis, F.; Pescitelli, G.; Prokhorenko, V. I.; Riedel, G.; Smeureanu, G.; Zeller, J.* “Syntheses and Energy Transfer in Multiporphyrinic Arrays Self-Assembled with Hydrogen-Bonding Recognition Groups and Comparison with Covalent Steroidal Models” Chem. Eur. J. 2007, 13, 8411-8427.p