Shafieichaharberoud, F.; Lang, S.; Whalen, C.; Quiles, C. R.; Purcell, L.; Talbot, C.; Wang, P.; Norton, E. B.; Mazei-Robison, M.; Sulima, A.; Jacobson, A. E.; Rice, K. C.; Matyas, G. R.; Huang, X.* “Enhancing protective antibodies against opioids through antigen display on virus-like particles” Bioconjugate Chem. 2024, in press.

H. Dong; X. Huang; X. Wu. “Development of a novel sialic acid-conjugated camptothecin prodrug for enhanced cancer chemotherapy” Biomaterials Science 2023, 11, 6160-6166.

Juhong, A., Li, B., Liu, Y., Yao, C.-Y., Yang, C.-W., Agnew, D. W., Lei, Y. L., Luker, G. D., Bumpers, H., Huang, X., Piyawattanametha, W., Qiu, Z., “Recurrent and convolutional neural networks for sequential multispectral optoacoustic tomography (MSOT) imaging” J. Biophotonics 2023, 16, e202300142.

Rashidijahanabad, Z., Ramadan, S., O'Brien, N. A., Nakisa, A., Lang, S., Crawford, H., Gildersleeve, J. C., Huang, X., “Stereoselective Synthesis of Sialyl Lewisa Antigen and the Effective Anticancer Activity of Its Bacteriophage Qβ Conjugate as an Anticancer Vaccine” Angew. Chem. Int. Ed. 2023, 62, e202309744.

Pascual, N.; Belecciu, T.; Schmidt, S.; Nakisa, A.; Huang, X.; Woldring, D.,* “Single-Cell B-Cell Sequencing to Generate Natively Paired scFab Yeast Surface Display Libraries” In Genotype Phenotype Coupling: Methods and Protocols, Zielonka, S.; Krah, S., Eds. Springer US: New York, NY, 2023; pp 175-212.

Chen, J.; Woldring, D. R.; Huang, F.; Huang, X.; Wei, G.-W.* “Topological deep learning based deep mutational scanning” Comput. Biol. Med. 2023, 164, 107258.

Juhong, A.; Li, B.; Yao, C.; Yang, C.; Liu, K.; Agnew, D.; Lei, Y.; Luker, G.; Bumpers, H.; Huang, X.; Piyattanametha, W.; Qiu, Z.* “Cost-effective Near Infrared Fluorescence Wide-Field Camera for Breast Tumor Imaging” IEEE Photon. Technol. Lett., 2023, 15, 813-816.

Wang, L.; Sorum, A.; Huang, B.-S.; Su, G.; Pawar, N.; Huang, X.; Liu, J.; Pohl, N.; Hsieh-wilson, L.* “Efficient Platform for Synthesizing Comprehensive Heparan Sulfate Oligosaccharide Libraries for Decoding Glycosaminoglycan-Protein Interactions” Nature Chem. 2023, 15, 1108–1117.

Baryal, K.; Ramadan, S.; Su, G.; Huo, C.-X.; Zhao, Y.; Liu, J.; Hsieh-wilson, L.; Huang, X.* “Synthesis of a Systemic 64 Membered Heparan Sulfate Tetrasaccharide Library” Angew. Chem. Int. Ed. 2023, 62, e202211985. (Rated by the editor as a Hot Paper. Highlighted as a Frontpiece of the issue)

Gao, Y.; Wang, W.; Yang, Y.; Zhao, Q.; Yang, C.; Jia, X.; Liu, Y.; Zhou, M.; Zeng, W.; Huang, X.; Chiu, S.;* Jin, T.;* Wu, X.* “Developing next-generation protein-based vaccines using high-affinity glycan ligand decorated glyconanoparticles” Adv. Sci. 2023, 10, 2204598.

Liu,K.; McCue, W. M.; Yang, C.; Finzel, B. C.; Huang, X.* “Combinatorial synthesis of a hyaluronan based polysaccharide library for enhanced CD44 binding” Carbohydr. Polym., 2023, 300, 120255.

Juhong, A.; Li, B.; Yao, C.; Yang, C.; Agnew, D.; Lei, Y.; Huang, X.; Piyattanametha, W.; Qiu, Z.* “Super-resolution and Segmentation Deep Learning for Breast Cancer Histopathology Image Analysis” Biomed. Opt. Express, 2023, 14, 18-36.

Sun, M.; Zhang, C.; Sui, D.; Yang, C.; Pyeon, D.; Huang, X.;* Hu, J.* “Rational design and synthesis of D-galactosyl lysophospholipids as selective substrates and non-ATP-competitive inhibitors of phosphatidylinositol phosphate kinases” Chem. Eur. J. 2023, 29, e202202083.


Yang, C.; Liu, K.; Yao, C.; Li, B.; Juhong, A.; Qiu, Z.;* Huang, X.* “Indocyanine Green Conjugated Superparamagnetic Iron Oxide Nanoworm for Multimodality Breast Cancer Imaging” ACS Appl. Nano Mater., 2022, 12, 18912-18920.

Li, T.;* Peng, P.; Huang, X. Sulfated Glycoprotein Synthesis. In: Li, X. (eds) Chemical Protein Synthesis. Methods in Molecular Biology, 2022, vol 2530. Humana, New York, NY.

Temme, J. S.; Crainic, J. A.; Walker, L. M.; Yang, W.; Tan, Z.; Huang, X.; Gildersleeve, J. C.* “Microarray-guided evaluation of the frequency, B cell origins, and selectivity of human anti-glycan antibodies reveals new insights and novel antibodies” J. Biol. Chem. 2022, 298,102468.

Orr, A.; Liu, K.; Mullick, A.; Huang, X.; Watts, S. W.* “Divergence of Chemerin Reduction Abilities of ATS9R Nanoparticle Targeting Adipose Tissue in vitro vs in vivo in the Rat” Biomedicines, 2022, 10, 1635.

Zhang, J.; Liang, L.; Yang, W.; Ramadan, S.; Baryal, K.; Huo, C.-X.; Bernard, J. J.; Liu, J.; Hsieh-wilson, L.; Zhang, F.; Linhardt, R. J.; Huang, X.* “Expedient Synthesis of a Library of Heparan Sulfate Like “Head to Tail” Linked Multimers for Structure and Activity Relationship Studies” Angew. Chem. Int. Ed. 2022, 61, e202209730.

Wang, P.; Ramadan, S.; Dubey, P.; Deora, R. Huang, X.* “Development of carbohydrate based next-generation anti-pertussis vaccines” Bioorg. Med. Chem. 2022, 74, 117066.

Chugh, S.; Swenson, C.; Yuzbasiyan-Gulkan, V.; Huang, X.* “Development of a Synthetic Peptide-Based Vaccine Candidate Against Bovine Leukemia Virus” ACS Infect. Dis. 2022, 8, 1031–1040.

Ramadan, S.; Su, G.; Baryal, K.; Hsieh-wilson, L.; Liu, J.; Huang, X.* “Automated Solid Phase Assisted Synthesis of a Heparan Sulfate Disaccharide Library” Org. Chem. Front. 2022, 9, 2910-2920. Selected by the editor as an Organic Chemistry Frontiers HOT article.

Sungsuwan, S.; Wu, X.; Kavunja, H.; McFall-Boegeman, H.; Lang, S.; Rashidijahanabad, Z.; Nick, S. T.; Shaw, V.; Yin, Z.; Jin, X.*; Huang, X.* “Structure Guided Design of Bacteriophage Qβ Mutants as Next Generation Carriers for Conjugate Vaccines” ACS Chem. Biol. 2022,17, 3047-3058.

McFall-Boegeman, H.;* Huang, X.* “Mechanisms of Cellular and Humoral Immunity Through the Lens of VLP-Based Vaccines” Expert Rev. Vaccines 2022, 21, 453-469.

Rashidijahanabad, Z.; Kelly, M.; Kamruzzaman, M.; Qadri, F.; Bhuiyan, T. R.; McFall-Boegeman, H.; Wu, D.; Piszczek, G.; Xu, P.;* Ryan, E. T.;* Huang, X.* “Virus like particle display of Vibrio cholerae O-specific polysaccharide as a potential vaccine against cholera” ACS Infect. Dis. 2022, 8, 574-583.
This work has been highlighted by multiple news websites:
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Dong, H.; Gao, Y.; Huang, X.; Wu, X.* “Synthesis of sialic acid conjugates of the clinical near-infrared dye as next-generation theranostics for cancer phototherapy” J. Mater. Chem. B., 2022, 10, 927-934.

Liu, K.; Huang, X.* “Synthesis of self-assembled hyaluronan based nanoparticles and their applications in targeted imaging and therapy” Carbohydr. Res. 2022, 511, 108500. Special issue in memory of Dr. Bertram Fraser-Reid.

Hossaini Nasr, S.; Huang, X.* “Nanotechnology for Targeted Therapy of Atherosclerosis” Front. Pharmacol., 2022, 12:755569. Special issue of “Advances on Targeted Nanomedicines for Atherosclerosis”


Qin, Q.; Lang, S.; Huang, X.* “Synthetic Linear Glycopolymers and Their Biological Applications” J. Carbohydr. Chem. 2021, 40, 1-44.

Gao, Y.; Zhao, Q.; Xiao, M.; Huang, X.; Wu, X.* “Developing acid-responsive glyco-nanoplatform based vaccines for enhanced cytotoxic T cell responses against cancer and SARS-CoV-2” Adv. Funct. Mater. 2021, 31, 2105059

Gao, J.; Huang, X.* “Recent Advances on Glycosyltransferases Involved in the Biosynthesis of Proteoglycan Linker Region” Adv. Carbohydr. Chem. Biochem. 2021, 80, 95-119.

Jung, J.; Enterina, J. R.; Bui, D. T.; Mozahen, F.; Lin, P.-H.; Nitin; Kuo, C.-W.; Rodrigues, E.; Bhattacherjee, A.; Raeisimakiani, P.; Daskhan, G. C.; St. Laurent, C. D.; Khoo, K.-H.; Mahal, K. K.; Zandberg, W. F.; Huang, X.; Klassen, J. S.; Macauley, M. S.* “Carbohydrate Sulfation as a Mechanism for Fine-tuning Siglec Ligands” ACS Chem. Biol. 2021, 16, 11, 2673–2689.

Wu, X.; Ye, J.; Kavunja, H.; DeLaitsch, A.; Rashidijahanabad, Z.; Lang, S.; Kakeshpour, T.; Zhao, Y.; Ramadan, S.; Vilar Saavedra, P.; Yuzbasiyan-Gurkan, V.; Cao, H.*; Gildersleeve, J. C.*; Huang, X.* “Chemoenzymatic Synthesis of 9NHAc-GD2 Antigen to Overcome Hydrolytic Instability of O-Acetylated-GD2 for Anticancer Conjugate Vaccine Development” Angew. Chem. Int. Ed. 2021, 60,24179–24188.

Wang, X.; Luo, X.; Tian, Y.; Wu, T.; Weng, J.; Li, J.*; Ye, F.*; Huang, X.* “Equipping Natural Killer Cells with Cetuximab through Metabolic Glycoengineering and Bioorthogonal Reaction for Targeted Treatment of KRAS Mutant Colorectal Cancer” ACS Chem. Biol. 2021, 16, 724-730.

Gao, Y.; Zhao, Q.; Xiao, M.; Huang, X.; Wu, X.* “A Versatile Photothermal Vaccine Based on Acid-responsive Glyconanoplatform for Synergistic Therapy of Cancer” Biomaterials, 2021, 273, 120792.

Gao, J.; Lin, P.-H., Nick, S. T.; Liu, K.; Yu, K.; Hohenester, E.; Huang, X. “Exploration of Human Xylosyltransferase for Chemoenzymatic Synthesis of Proteoglycan Linkage Region” Org. Biomol. Chem. 2021, 19, 3374 – 3378.

Wu, X.; McFall-Boegeman H.; Rashidijahanabad, Z.; Liu, K.; Pett, C.; Yu, J.; Schorlemer, M.; Ramadan, S.; Behren, S.; Westerlind, U.; Huang, X. “Synthesis and Immunological Evaluation of the Unnatural β-linked Mucin-1 Thomsen-Friedenreich Conjugate” Org. Biomol. Chem. 2021,19, 2448-2455.

Gao, J.; Xu, Y.; Liu, J.; Huang, X. “Convergent Chemoenzymatic Synthesis and Biological Evaluation of a Heparan Sulfate Proteoglycan Syndecan-1 Mimetic” Chem. Commun., 2021, 57, 3407-3410.

Wang, P.; Zhao, J.; Hossaini Nasr, S.; Otieno, S. A.; Zhang, F.; Qiang, W.;* Linhardt, R. J.;* Huang, X.* “Probing Aβ Interactions with Synthetic Heparan Sulfate Oligosaccharides” ACS Chem. Biol. 2021, 16, 1894-1899

Gao, J.; Lin, P.; Nick, S. T.; Huang, J.; Tykesson, E.; Ellservik, U.; Li, J.; Huang, X.* “Chemoenzymatic Synthesis of Glycopeptides bearing Galactose-xylose Disaccharide from the Proteoglycan Linkage Region” Org. Lett., 2021, 23, 5, 1738–1741.

Li, Y.; Qian, D.; Lin, H.-P.; Xie, J.; Yang, P.; Maddy, D.; Xiao, Y.; Huang, X.; Wang, Z.;* Yang, C.* “Nanoparticle-delivered Miriplatin Ultrasmall Dots Suppress Triple Negative Breast Cancer Lung Metastasis by Targeting Circulating Tumor Cells” J. Control. Release 2021, 329, 833-846.

Yang, W.; Zhang, J.; Yang, C.-W.; Ramadan, S.; Staples, R.; Huang, X.* “Long Range Stereodirecting Participation across a Glycosidic Linkage in Glycosylation Reactions” Org. Lett. 2021, 23, 1153-1156.
This work has made the journal back cover.

Zhao, Q.; Gao, Y.; Xiao, M.; Huang, X.; Wu, X.* “Synthesis and Immunological Evaluation of Synthetic Peptide Based anti-SARS-CoV-2 Vaccine Candidates” Chem. Commun. 2021, 57, 1474-1477


Li, T.; Ramadan, S.; Yang, W.; Huang, X.* “Synthesis of O-Sulfated Human Syndecan-1-like Glyco-polypeptides by Incorporating Peptide Ligation and O-Sulfated Glycopeptide Cassette Strategies” Org. Lett. 2020, 22, 6429–6433.

Zhang, J.; Huang, X.* “Heparin Mimetics as Tools for Modulation of Biology and Therapy” in Carbohydrates in Drug Discovery & Development, Elsevier, Editor: Dr. Vinod Kumar Tiwari, 2020, 71-96.

Lang, S.;Tan, Z; Wu, X.; Huang, X.* "Synthesis of Carboxy-Dimethylmaleic Amide Linked Polymer Conjugate Based Ultra-pH-sensitive Nanoparticles for Enhanced Antitumor Immunotherapy" ACS Macro Lett. 2020, 9, 1693-1699.

Yang, W.; Eken, Y.; Zhang, J; Cole, L. E.; Ramadan, S.; Xu. Y.; Zhang, Z.; Liu, J.; Wilson, A. K.; Huang, X.* “Chemical Synthesis of Human Syndecan-4 Glycopeptide Bearing O-, N-sulfation and Multiple Aspartic Acids for Probing Impacts of the Glycan Chain and the Core Peptide on Functions” Chem. Sci. 2020, 11, 6393-6404.
This work has been highlighted as back cover of the issue.
This paper is part of the 2020 Chemical Science HOT Article Collection and the themed collection: Celebrating 10 years of Chemical Science.

Dhara, D., Baliban, S. M.; Huo, C.-X.; Rashidijahanabad, Z.; Sears, K. T.; Nick, S. T.; Misra, A. K.; Tennant, S. M.; Huang, X.* “Syntheses of Salmonella Paratyphi A Associated Oligosaccharide Antigens and Development towards Anti-paratyphoid Fever Vaccines” Chem. Eur. J. 2020, 68, 15953-15968

Ramadan, S.; Li, T.; Yang, W.; Zhang, J.; Rashidijahanabad, Z.; Tan, Z.; Parameswaran, N.; Huang, X.* "Chemical Synthesis and Anti-Inflammatory Activity of Bikunin Associated Chondroitin Sulfate 24-mer" ACS Cent. Sci., 2020, 6, 913-920.
This work has made the journal cover.

Wang, P.; Huo, C.-X.; Lang, S.; Caution, K.; Nick, S. T.; Dubey, P.; Deora, R.* Huang, X.* “Chemical Synthesis and Immunological Evaluation of Pertussis-Like Pentasaccharide Bearing Multiple Rare Sugars as a Potential Anti-pertussis Vaccine” Angew. Chem. Int. Ed. 2020, 59, 6451-6458.
Highlighted in Synfacts 2020, 16, 0471.

Wang, X.; Lang, S.; Tian, Y.; Zhang, J.; Yan, X.; Fang, Z.; Weng, J.; Lu, N.; Wu, X.; Li, T.; Cao, H.; Li, Z.;* Huang, X.* “Glyco-engineering of Natural Killer Cells with CD22 Ligands for Enhanced Anti-cancer Immunotherapy” ACS Cent. Sci. 2020, 6, 382-389.
This paper has made the journal cover.

Wang, P.; Kim, T.; Harada, M.; Contag, C.; Huang, X.; Smith, B. R.* “Nano-immunoimaging” Nanoscale Horiz. 2020, 5, 628-653.

Rashidijahanabad, Z.; Huang, X.* “Recent Advances in Tumor Associated Carbohydrate Antigen Based Chimeric Antigen Receptor T Cells and Bispecific Antibodies for Anti-cancer Immunotherapy Nano-immunoimaging” Semin. Immunol. 2020, 47, 10139.

Hossaini Nasr, S.; Ramadan, S.; Rashidijahanabad, Z.; Kauffman, N.; Parameswaran, N.; Zinn, K.; Qian, C.; Arora, R.; Agnew, D.; Huang, X.* “Effective Atherosclerotic Plaque Inflammation Inhibition with Targeted Drug Delivery by Hyaluronan Conjugated Atorvastatin Nanoparticles” Nanoscale 2020, 12, 9541-9556.

Lang, S.; Huang, X.* “Carbohydrate Conjugates in Vaccine Developments” Front. Chem. 2020, 8:284.


Wu. X.; McKay, C.; Pett, C.; Yu, J.; Schorlemer, M.; Ramadan, S.; Lang, S.; Westerlind, U.; Finn, M. G.; Huang, X.* “Synthesis and Immunological Evaluation of Disaccharide bearing MUC-1 Glycopeptide Conjugates with Virus-Like Particle to Reduce Tumor Metastasis” ACS. Chem. Biol. 2019, 14, 2176-2184.
This paper has made the journal cover.

Li, Y.;Xiao, Y.;lin, H.;Reichel, D.;Bae, Y.;Lee, E.;Jiang, Y.;Huang, X.;Yang, C.and Wang, Z.;"In vivo β-catenin attenuation by the integrin α5-targeting nano-delivery strategy suppresses triple negative breast cancer stemness and metastasis" Biomaterials, 2019, 188, 160-172

Pawar, N. J.; Wang, L.; Higo, T.; Bhattacharya, C.; Kancharla, P. K.; Zhang, F.; Baryal, K.; Huo, C.-X.; Liu, J.; Linhardt, R. J.; Huang, X.; Hsieh-Wilson, L.* “Expedient Synthesis of Core Disaccharide Building Blocks from Natural Polysaccharides for Heparan Sulfate Oligosaccharide Assembly” Angew. Chemie. Int. Ed. 2019, 58, 18577-18583.

Nilsson, J.; Brinkmalm, G.; Ramadan, S.; Gilborne, L.; Noborn, F.; Blennow, K.; Wallin, A.; Svensson, J.; Abo-Riya, M. A.; Huang, X.*, Larson, G.* “Synthetic Standard Aided Quantification and Structural Characterization of Amyloid-beta Glycopeptides Enriched from Cerebrospinal Fluid of Alzheimer’s Disease Patients”, Sci. Rep. 2019, 9, 5522

Huo, C.-X.; Dhara, D., Baliban, S. M.; Nick, S. T.; Tan, Z.; Simon, R.; Misra, A. K.; Huang, X.* “Synthetic and Immunological Studies of Salmonella Enteritidis O-antigen Tetrasaccharide as Potential Anti-Salmonella Vaccines” Chem. Commun. 2019, 55, 4519-4522.

Ramadan, S.; Yang, W.; Huang, X.* “Synthesis of Chondroitin Sulfate Oligosaccharides and Chondroitin Sulfate Glycopeptides” in Synthetic Glycome, Royal Society of Chemistry; Editor: Peng George Wang; 2019, 172-206 (invited chapter).


Yin, Z.; Wu. X.; Kaczanowska, K.; Sungsuwan, S.; Comellas-Aragones, M.; Pett C., Yu J.; Baniel, C.; Westerlind, U.; Finn, M. G.; Huang, X.* “Antitumor Humoral and T Cell Responses by Mucin‑1 Conjugates of Bacteriophage Qβ in Wild-type Mice” ACS Chem. Biol. 2018, 13, 1668-1676.

Wu, X.;Yin, Z.;McKay, C.; Pett, C.;Yu, J.;Schorlemer, M.;Gohl, T.; Sungsuwan, S.;Ramadan, S.;Baniel, C.;Allmon, A.; Das, R.;Westerlind, U.;Finn, M.G.and Huang, X.;* "Protective Epitope Discovery and Design of MUC1-based Vaccine for Effective Tumor Protections in Immunotolerant Mice", J. Am. Chem. Soc.2018, 140, 16596-16609

Yang, W.; Ramadan, S.; Orwenyo, J.; Kakeshpour, T.; Diaz, T.; Eken, Y.; Sanda, M.; Jackson, J.;* Wilson, A.;* Huang, X.* “Chemoenzymatic Synthesis of Glycopeptides Bearing Rare N-Glycan Sequences with or without Bisecting GlcNAc” Chem. Sci. 2018, 9, 8194-8206

Wang, P.; Cascio, F.; Gao, J.; Kayed, R. and Huang, X.* "Binding and neurotoxicity mitigation of toxic tau oligomers by synthetic heparin like oligosaccharides", Chem.Comm.2018, 54, 10120-10123

Hossaini Nasr, S.; Kouyoumdjian, H.; Mallet, C.; Ramadan, S.; Zhu, D. A.; Shapiro, E. M.; Huang, X.* “In vivo Detection of β-amyloid by Sialic Acid Decorated Bovine Serum Albumin Magnetic Nanoparticles in a Mouse Model of Alzheimer’s Disease”, Small, 2018, 14, 1701828
This work has been highlighted by Nature Middle East

Xu, S.; Hossaini Nasr, S.; Chen, D.; Zhang, X.; Sun, L.; Huang, X.;* Qian, C.* “MiRNA Extraction from Cell-free Biofluid using Protein Corona Formed around Carboxyl Magnetic Nanoparticles” ACS Biomate. Sci. Eng. 2018, 4, 654-662.

Hossaini Nasr, S.; Tonson, A.; El-dakdouki, M. H.; Agnew, D.; Zhu, D. A.; Wiseman, R.; Qian, C.;* Huang, X.* “Effects of Nanoprobe Morphology on Cellular Binding and Inflammatory Responses: Hyaluronan Conjugated Magnetic Nanoworms for Magnetic Resonance Imaging of Atherosclerotic Plaques”, ACS Appl. Mater. Interface 2018, 10, 11495-11507.

Yang, B.; Yang, W.; Ramadan, S.; Huang, X.* “Pre-activation Based Stereoselective Glycosylations” Eur. J. Org. Chem., 2018, 1075-1096.
This paper has made the journal cover


Yang, W.; Yang, B.; Ramadan, S.; Huang, X.* “Pre-activation Based Chemoselective Glycosylations: A Powerful Strategy for Oligosaccharide Assembly” Beilstein J. Org. Chem., 2017, 13, 2094-2114. PMCID: PMC5647719.

Sungsuwan, S.; Wu, X.; Huang, X.* “Evaluation of Virus Like Particle Based Tumor-Associated Carbohydrate Immunogen in a Mouse Tumor Model” in Methods in Enzymology, Elsevier; Editor: Barbara Imperiali; 2017, 597, 359-376 (invited chapter).p PMCID: PMC5772760.

Ramadan, S.; Yang, W.; Zhang, Z.; Huang, X.* “Synthesis of Chondroitin Sulfate A Bearing Syndecan-1 Glycopeptide”, Org. Lett., 2017, 19, 4838-4841. PMCID: PMC5772981.

Ramadan, S.; Yang, W.; Huang, X.* “Synthesis towards Heparan Sulfate Glycopeptides and Proteoglycans” in Chemical Biology of Glycoproteins, Royal Society of Chemistry; Editor: Zhongping Tan, Lai-xi Wang; 2017, 209-232 (invited chapter). DOI:10.1039/9781782623823-00209

Kavunja, H.; Lang, S.; Sungsuwan, S.; Yin, Z.; Huang, X.* “Delivery of Foreign Cytotoxic T-lymphocyte Epitope to Tumor Tissues for Effective Antitumor Immunotherapy against Pre-established Solid Tumor” Cancer Immunol. Immunother. 2017, 66, 451-460.


Thapa, R.*; Gorski, J.; Bogedin, A.; Maywood, M.; Clement, C.; Hossaini-Nasr, S.; Hanna, D.; Huang, X.; Roth, B. J.; Madlambayan, G.; Wilson, G. D. “Hyaluronan-mediated ferric oxide nanoparticles causes apoptosis of CD44 expressing head and neck squamous cell carcinoma cells” Int. J. Cancer Ther. Oncol. 2016, 4, 424.

Haro, M.; Littrell, C.; Yin, Z.; Huang, X.; Haas, K.* "PD-1 Suppresses Development of Humoral Responses That Protect against Tn-Bearing Tumors" Cancer Immunology Research 2016, 4, 1-11.

Li, Y.; Humphries, B.; Wang, Z.; Lang, S.; Huang, X.; Xiao, H; Jiang, Y.; Yang, C.* "Complex Coacervation-Integrated Hybrid Nanoparticles Increase Plasmid DNA Delivery Efficiency in vivo" ACS Appl. Mater. Interfaces 2016, 8, 30735-30746

Yang, W.; Yoshida, K; Yang, B.; Huang, X.* "Obstacles and solutions for chemical synthesis of syndecan-3 (53–62) glycopeptides with two heparan sulfate chains" Carbohydrate Res. 2016, 435, 180-194.

Yang,W.;Ramadan, S.;Yang, B.;Yoshida, K; Huang, X.* "Homoserine as an Aspartic Acid Precursor for Synthesis of Proteoglycan Glycopeptide Containing Aspartic Acid and Sulfated Glycan Chain" J. Org. Chem 2016,81, 12052-12059

Ramadan, S.; Yang, W.; Huang, X.* “Synthesis towards Heparan Sulfate Glycopeptides and Proteoglycans” in Chemical Biology of Glycoproteins, Royal Society of Chemistry; Editor: Zhongping Tan, Lai-xi Wang; 2017,209-232.

Yang, B.; Yoshida, K.; Huang, X.*; "strategies for one-pot synthesis of oligosaccharides in glycochemical synthesis: strategies and applications", Wiley-Blackwell; Editor: Shang-cheng Hung,2016,155-188.

Qin, Q.; Yin, Z.; Haas, K. M.; Huang, X.* “Valency and Density Matter: the Impacts of Immunogen Structures on Early B Cell Activation and Antibody Generation against a Tumor Associated Carbohydrate Antigen” Biomaterials 2016, 101, 189-198.

Guo, R.; Gaffney, K.; Yang, Z.; Kim, M.; Sungsuwan, S.; Huang, X.; Hubbell, W.; Hong, H.* “Steric Trapping Reveals a Cooperativity Network in the Intramembrane Protease GlpG under Native Condition” Nat. Chem. Biol. 2016, 12, 353–360.

Yin, Z.; Dulaney, S.: McKay, C. S.; Baniel, C.; Kaczanowska, K.; Ramadan, S.; Finn, M. G.; Huang, X.* “Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ and the Induction of Anti-Cancer Antibodies” ChemBiochem. 2016, 17, 174-180.


Thapa, R.;* Galoforo, S.; Kandel, S. M.; El-dakdouki, M. H.; Wilson, T. G.; Huang, X.; Roth, B. J.; Wilson, G. D. “Radiosensitizing and Hyperthermic Properties of Hyaluronan Conjugated, Dextran Coated Ferric Oxide Nanoparticles: Implications for Cancer Stem Cell Therapy” J. Nanomateirals 2015, doi:10.1155/2015/840594.

Vyas, D.;* Lopez-Hisijos, N.; Gandhi, S.; El-Dakdouki, M.; Basson, M. D.; Walsh, M. F.; Huang, X.; Vyas, A. K.; Chaturvedi, L. S. “Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells” J. Nanosci. Nanotechnol. 2015, 15, 6413-6422

Dulaney, S. B.; Xu, Y.; Wang, P.; Tiruchinapally, G.; Wang, Z.; Kathawa, J.; El-Dakdouki, M. H.; Yang, B.; Liu, J.; Huang, X.* “Divergent Synthesis of Heparan Sulfate Oligosaccharides” J. Org. Chem. . 2015, 80, 12265-12279.

Sungsuwan, S.; Yin, Z.; Huang, X.* “Lipopeptide Coated Iron Oxide Nanoparticles as Potential Glyco-Conjugate Based Synthetic Anti-Cancer Vaccines” ACS Appl. Mater. Interface 2015, 7, 17535−17544.

Yin, Z.; Wright, W. S.; McKay, C.; Baniel, C.; Kaczanowska, K.; Bentley, P.; Gildersleeve, J. C.; Finn, M. G.; BenMohamed, L.; Huang, X.* “Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-based Anti-cancer Vaccine” ACS Chem. Biol., 2015, 10 (10), 2364–2372

Lu, X.; Huang, X.* “Design and Syntheses of Hyaluronan Oligosaccharide Conjugates as Inhibitors of CD44-Hyaluronan Binding” Glycoconjugate J. 2015, 32,549-556(special issue dedicated to Chemical Glycobiology).

Zhou, W.; Hsieh, P.-H., Xu, Y.; Huang, X., Liu, J.* “Design and Synthesis of Active Heparan Sulfate-based Probes” Chem. Commun. 2015, 51, 11019-11021.

Kouyoumdjian, H.; Huang, X.* “Sialic Acid Modified Nanoparticles for β-Amyloid Studies” inCarbohydrate Nanotechnology, Wiley; Editor: Keith Stine; 2015, (invited chapter)

Yin, Z.; Huang, X.* “Boosting Humoral Immune Responses to Tumor Associated Carbohydrate Antigens with Virus-like Particles” in Carbohydrates in Drug Design and Discovery, Royal Society of Chemistry, UK; Editor: Jesus Jimenez-Barbero; 2015, 132-149 (invited chapter). 10.1039/9781849739993

Kavunja, H.; Voss, P. G.; Wang, J.;* Huang, X.* “Identification of Lectins from Metastatic Cancer Cells through Magnetic Glyco-nanoparticles” Israel J. Chem. 2015, 55, 423-436. (Special issue dedicated to Dr. Chi-Huey Wong’s Wolf Prize).

Wang, P.; Kouyoumdjian, H.; Zhu, D. C.; Huang, X.* Heparin Nanoparticles for β Amyloid Binding and Mitigation of β Amyloid Associated Cytotoxicity, Carbohydr. Res. 2015, 405, 110-114. (Special issue dedicated to glyco-nanomaterials). PMCID: PMC4314519.


Wang, P.; Nilsson, J.; Brinkmalm, G.; Larson, G.*; Huang, X.* Synthesis and Structural Determination of Amyloid-β (1-15) Glycopeptide, a New Biomarker for Alzheimer’s Disease Chem. Commun. 2014,50,15067-15070

Qin, Q.; Yin, Z.; Bentley, P.; Huang, X.* Carbohydrate Antigen Delivery by Water Soluble Copolymers as Potential Anti-cancer Vaccines, Med. Chem. Commun. 2014, 5, 1126-1129 (This article was highlighted as the inside cover of the issue)

Yoshida, K.; Yang, B.; Yang, W.; Zhang, Z.; Zhang, J. Huang, X.* Chemical Synthesis of Human Syndecan-3 Glycopeptides Bearing Two Heparan Sulfate Glycan Chains, Angew. Chem. Int. Ed. 2014, 53, 9051-9058

El-dakdouki, M; Xia, J; Zhu, D. C.; Kavunja, H.; Grieshaber, J.; O'Reilly, S.; McCormick, J. J.; Huang, X.* Assessing the in Vivo Efficacy of Doxorubicin Loaded Hyaluronan Nanoparticles, ACS Appl. Mater. Interface, 2014, 6, 697–705

El-dakdouki, M.; El-boubbou, K.; Kamat, M.; Huang, R.; Abela, G.; Zhu, D. C.*; Huang, X.* CD44 Targeting Magnetic Glyconanoparticles for Atherosclerotic Plaque Imaging, Pharm Res. 2014, 31, 1426-1437 (Highlighted as front cover of the issue)

El-dakdouki, M.; El-boubbou, K.; Xia, J.; Kavunja, H.; Huang, X.* Methods for Magnetic Nanoparticle Synthesis and Functionalization Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications Editor: Ravin Rarain, John Wiley & Sons, 2014, pp 281-314


Wasonga, G.; Tatara, Y.; Kakizaki, I.; Huang, X.* Synthesis of N-Acetyl Glucosamine Analogs as Inhibitors for Hyaluronan Biosynthesis, J. Carbohydr. Chem. 2013, 32, 392-409

Huang, X.; Vocadlo, D. Reports from the Award Symposia Hosted by the American Chemical Society, Division of Carbohydrate Chemistry at the 245th American Chemical Society National Meeting, ACS Chem. Biol. 2013, 8, 1361-1365

Yin, J.; Comellas-Aragones, M.; Chowdhury, S.; Bentley, P.; Kaczanowska, K.; BenMohamed, L.; Gildersleeve, J. C.; Finn, M.G.; Huang, X.* Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids, ACS Chem. Biol., 2013, 8, 1253-1262
This work has been highlighted by Chemical & Engineering News as well as in the June 2013 POD cast from ACS Chemical Biology

El-dakdouki, M.; Puré, E.; Huang, X.* Development of Drug Loaded Nanoparticles for Tumor Targeting. Part 2: Enhancement of Tumor Penetration Through Receptor Mediated Transcytosis in 3D Tumor Models, Nanoscale, 2013, 5, 3904-3911

El-dakdouki, M.; Puré, E.; Huang, X.* Development of Drug Loaded Nanoparticles for Tumor Targeting. Part 1: Synthesis, Characterization, and Biological Evaluation in 2D Cell Cultures, Nanoscale, 2013, 5, 3895-3903

Kouyoumdjian, H.; Zhu, D. C.; El-Dakdouki, M. H.; Lorenz, K.; Chen, J.; Li, W.; Huang, X.* Glyconanoparticle Aided Detection of β-Amyloid by Magnetic Resonance Imaging and Attenuation of β-Amyloid Induced Cytotoxicity, ACS Chem. Neurosci., 2013, 4, 575−584


Yang, B.; Yoshida, K.; Yin, Z.; Dai, H.; Kavunja, H.; El-Dakdouki, M. H.; Sungsuwan, S.; Dulaney, S. B.; Huang, X.* Chemical Synthesis of Homogeneous Syndecan-1 Heparan Sulfate Glycopeptide, Angew. Chem. Int. Ed., 2012, 51, 10185-10189

Yin, Z.; Nguyen, H. G.; Chowdhury, S.; Bentley, P.; Bruckman, M. A.; Miermont, A.; Gildersleeve, J. C.; Wang, Q.; Huang, X.* Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens, Bioconjugate Chem., 2012, 23, 1694-1703. NIHMSID: 396464

Huang, X. Foreword, J. Carbohydr. Chem., 2012, 31, 253-254 Foreword to the Special Issue Dedicated to the 7th Midwest Carbohydrate and Glycobiology Symposium

Sheng, J.; Xu, Y.; Dulaney, S. B.; Huang, X.; Liu, J.* Uncovering a Biphasic Catalytic Mode of C5-epimerase in Heparan Sulfate Biosynthesis, J. Biol. Chem., 2012, 287, 20996-21002

Xu. Y.; Wang, Z.; Liu, R.; Bridges, A. S.; Huang, X.; Liu, J.* Directing the Biological Activities of Heparan Sulfate Oligosaccharides Using a Chemoenzymatic Approach, Glycobiology, 2012, 22, 96-106

Sun, B.; Yang, B.; Huang, X.* Total Synthesis of the Aminopropyl Functionalized Ganglioside GM1, Sci. China Chem., 2012, 55, 31-35

Li, H.; El-dakdouki, M.H.; Zhu, D. C.; Abela, G. S.; Huang, X.* Synthesis of b-cyclodextrin Conjugated Superparamagnetic Iron Oxide Nanoparticles for Detection of Cholesterol Crystals, Chem. Commun., 2012, 48, 3385-3387 (This article was highlighted as the back cover of the issue)

El-dakdouki, M.H.; Zhu, D. C.; El-Boubbou, K.; Kamat, M.; Chen, J.; Li, W.; Huang, X.* Development of Multifunctional Hyaluronic Acid Coated Nanoparticles: Targeted Imaging and Drug Delivery to Cancer Cells in vitro, Biomacromolecules, 2012, 13, 1144-1151

Dulaney, S. B.; Huang, X.* Recent Strategies in Heparin/heparan Sulfate Oligosaccharide Synthesis: 2000 – present, Adv. Carbohydr. Chem. Biochem., 2012, 67, 95-136 (invited review)

Yin, Z.; Huang, X.* Recent Development in Carbohydrate Based Anti-cancer Vaccines, J. Carbohydr. Chem., 2012, 31, 143-186


El-dakdouki, M.H.; El-Boubbou, K.; Zhu, D. C.; Huang, X.* A Simple Method for the Synthesis of Hyaluronic Acid Coated Magnetic Nanoparticles for Highly Efficient Cell Labeling and in vivo Imaging, RSC Adv., 2011, 1, 1449-1452

El-dakdouki, M.H.; Huang, X.* Biological Applications of Hyaluronic Acid Functionalized Nanomaterials, in Glyco-Nanotechnology as a Bridge to New Medicines, ACS symposium series, Editors: Huang, X.; Barchi, J. 2011, 181-213

Tiruchinapally, G.; Yin, Z.; El-dakdouki, M.H.; Wang, Z.; Huang, X.* Divergent Heparin Oligosaccharide Synthesis with Pre-installed Sulfate Esters, Chem. Eur. J., 2011, 17, 10106 – 10112

El-boubbou, K.; Huang, X.* Glyco-Nanomaterials: Translating Insights from the “Sugar-code” to Biomedical Applications, Curr. Med. Chem. , 2011, 18, 2060-2078

Deng, C. X.; Huang, X.* Improved Outcome of Targeted Delivery of Chemotherapy Drug to the Brain using a Combined Strategy of Ultrasound, Magnetic Targeting, and Drug Loaded Nanoparticles, Therapeutic Delivery , 2011, 2, 137–141

Li, X.; Zhou, H.; Yang, L.; Du, G.; Pai-Panandiker, A. S.; Huang, X.; Yan, B.* Enhancement of Cell Recognition in vitro by Dual-ligand Cancer Targeting Gold Nanoparticles, Biomaterials, 2011, 232, 2540-2545

Wasonga, G.; Zeng, Y.; Huang, X.* Pre-activation Based Stereoselective Glycosylations: Stereochemical Control by Additives and Solvent, Sci. China Chem., 2011, 54, 1, 66-73


Kamat, M.; El-Boubbou, K.; Zhu, D.; Lansdell, T.; Lu, X.; Li, W.; Huang, X.* Hyaluronic Acid Immobilized Magnetic Nanoparticles for Active Targeting and Imaging of Macrophages, Bioconjugate Chem., 2010, 21, 11, 2128–2135

Wang, Z.; Xu, Y.; Yang, B.; Tiruchinapally, G.; Sun, B.; Liu, R.; Dulaney, S.; Liu, J.; Huang, X.* Pre-activation-Based One-pot Combinatorial Synthesis of Heparin-like Hexasaccharides for the Analysis of Heparin–Protein Interactions, Chem. Eur. J., 2010, 16, 28, 8365-8375. (This article was rated by the reviewers as VIP publication)

El-Boubbou, K.; Zhu, D.; Vasileiou, C.; Borhan, B.; Prosperi, D.; Li, W.; Huang, X.* Magnetic Magnetic Glyco-Nanoparticles: A Tool To Detect, Differentiate, and Unlock the Glyco-Codes of Cancer via Magnetic Resonance Imaging, J. Am. Chem. Soc., 2010, 132, 12, 4490-4499.

Yang, B.; Jing, Y.; Huang, X.* Fluorous Assisted One-pot Oligosaccharide Synthesis. Eur. J. Org. Chem., 2010, 7, 1290–1298.

Wang, Y.; El-Boubbou, K.; Kouyoumdjian, H.; Sun, B.; Huang, X.; Zeng, X.* Lipoic Acid Carbohydrate Conjugates, a New Class of Agents for Controlling Nonspecific Adsorption of Blood Serum at Bio-interfaces for Biosensor and Biomedical Applications, Langmuir, 2010, 26, 4119-4125.


Lu, X.; Kamat, M. N.; Huang, L.; Huang, X.* Chemical Synthesis of a Hyaluronic Acid Decasaccharide, J. Org. Chem., 2009, 74, 7608-7617 (JOC Featured article)

Li, X.; Huang, L.; Hu, X.; Huang, X.* Thio-arylglycosides with Various Aglycon Para-Substituents, a Useful Tool for Mechanistic Investigation of Chemical Glycosylations, Org. Biomol. Chem., 2009, 7, 117-127.


Zeng, Y.; Wang, Z.; Whitfield, D., Huang, X.* Installation of Electron Donating Protective Groups, a Strategy for Glycosylating Unreactive Thioglycosyl Acceptors using the Pre-activation Based Glycosylation Strategy, J. Org. Chem., 2008, 73, 7952-7962.

Wang, Z.; Huang, X.* p-Toluenesulfenyl Chloride Electronic Encyclopedia of Reagents in Organic Synthesis, 2008.

Sun, B.; Srivinasan, B.; Huang, X.* Pre-activation Based One-pot Synthesis of an α-(2,3)-Sialylated Core-Fucosylated Complex Type Bi-antennary N-Glycan Dodecasaccharide, Chem. Eur. J., 2008, 14, 7072-7081

Wang, Z.; Gilbert, M.; Eguchi, H.; Yu, H.; Cheng, J.; Muthana, S.; Zhou, L.; Wang, P. G.; Chen, X.; Huang, X.* Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4, Adv. Synth. Catal., 2008, 350, 1717-1728.

Miermont, A.; Barnhill, H.; Strable, E.; Lu, X.; Wall, K. A.; Wang, Q.; Finn, M. G.; Huang, X.* Cowpea Mosaic Virus Capsid, a Promising Carrier towards the Development of Carbohydrate Based Anti-tumor Vaccines, Chem. Eur. J., 2008, 14, 4939-4947.

Huang, L.; Lu, X.; Huang, X.* Chemical Syntheses of Hyaluronic Acid Oligosaccharides, in Chemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, ACS symposium series, 2008.

Srinivasan, B.; Huang, X.* Functionalization of Magnetic Nanoparticles with Organic Molecules: Loading Level Determination and Evaluation of Linker Length Effect on Immobilization, Chirality , 2008, 20, 265-277. (Special issue dedicated to Prof. Nina Berova)


El-Boubbou, K.; Gruden, C.; Huang, X.* Magnetic Glyco-nanoparticles: A Unique Tool for Rapid Pathogen Detection, De-contamination and Strain Differentiation, J. Am. Chem. Soc., 2007, 129, 13392-13393.

Miermont, A.; Zeng, Y.; Jing, Y.; Ye, X.-S.; Huang, X.* Syntheses of LewisX and Dimeric LewisX: Construction of Branched Oligosaccharides by a Combination of Pre-activation and Reactivity Based Chemoselective One-Pot Glycosylations, J. Org. Chem. , 2007, 72, 8958-8961.

Teumelsan, N.; Huang, X.* Synthesis of Branched Oligomannans and an Unusual Stereochemical Observation, J. Org. Chem. , 2007, 72, 8976-8979.

Wang, Z.; Zhou, L.; El-boubbou, K.; Ye, X.-S.; Huang, X.* Four Component One-Pot Synthesis of the Tumor-Associated Carbohydrate Antigen Globo-H Based on Preactivation of Thioglycoside Donors. J. Org. Chem. , 2007, 72, 6409-6420.

Wang, Z.; Huang, X.* Strategies in Oligosaccharide Synthesis in Comprehensive Glycoscience. From Chemistry to Systems Biology 2007, Editor: J. P. Kamerling, Elsevier, p379-413.

Huang, L.; Huang, X.* Highly Efficient Syntheses of Hyaluronan Oligosaccharides, Chem. Eur. J. 2007, 13, 529-540.


Wang, C.; Wang, H.; Huang, X.; Zhang, L.-H.; Ye, X.-S.* Benzenesulfinyl Morpholine: A New Promoter for One-Pot Oligosaccharide Synthesis Using Thioglycosides by Pre-Activation Strategy, Synlett 2006, 2846-2850.

Huang, L.; Teumelsan, N.; Huang, X.* A Facile Method for Oxidation of Primary Alcohols to Carboxylic Acids and Its Application in Glycosaminoglycan Syntheses, Chem. Eur. J. 2006, 12, 5246-5252.

Huang, L.; Wang, Z.; Li, X.; Huang, X.* Iterative One-Pot Synthesis of Chitotetraose, Carbohydr. Res. 2006, 341, 1669-1679.


Huang, L.; Huang, X.* Methyl triflate, Electronic Encyclopedia of Reagents in Organic Synthesis, 2005.


Wang, Y.; Huang, X.; Zhang, L.-H.; Ye, X.-S.* A Four-Component One-Pot Synthesis of a-Gal Pentasaccharide Org. Lett. 2004, 6, 4415-4417.

Huang, X. Mercuric Bromide, Electronic Encyclopedia of Reagents in Organic Synthesis, 2004, RN00383.

Huang, X.*; Huang, L.; Wang, H.; Ye, X.-S. Iterative One-Pot Oligosaccharide Synthesis, Angew. Chem. Int. Ed. 2004, 5221-5224.

Huang, L.; Wang, Z.; Huang, X.* One-pot Oligosaccharide Synthesis: Reactivity Tuning by Post-synthetic Modification of Aglycon, Chem. Commun. 2004, 1960-1961.

Jing, Y.; Huang, X.* Fluorous Thiols in Oligosaccharide Synthesis, Tetrahedron Lett. 2004, 45, 4615-4618


Journal articles (Corresponding authors are highlighted with a *. Peer reviewed articles are designated with a p after the full citation.)

From Work Conducted During Undergraduate, Graduate and Postdoctoral Periods

1. Li, J.*; Zhang, J.; Huang, X.; Du, S.; Wu, X. “Crystal Structure of An Unusual Four Coordinated Copper (II) Complex Containing 1, 10-Phenanthroline and Salicyclic Acid” Cryst. Res. Technol. 1995, 30, 211-116.p

2. Li, J.*; Xu, M.; Huang, X.; Zhang, Y. “Spectroscopic and Structural Properties of Dichloro-(L-histidine) Copper (II) Crystal” Spec. Lett. 1995, 28, 111-118.p

3. Nakanishi, K.*; Huang, X.; Jiang, H.; Liu, Y.; Fang, K.; Huang, D.; Choi. S.-K.; Katz, E.; Eldefrawi, M.E. “Structure/binding Relation of Philanthotoxins from Nicotinic Acetylcholine Receptor Binding Assay” Bioorg. Med. Chem. 1997, 5, 1969-1988.p

4. Huang, X.; Rickman, B.; Borhan, B.; Bevora, N.; Nakanishi, K.* “Zinc Porphyrin Tweezer in Host-guest Complexation: Determination of Absolute Configurations of Diamines, Amino Acids, and Amino Alcohols by Circular Dichroism” J. Am. Chem. Soc. 1998, 120, 6185-6186.p

5. Huang, X.; Borhan, B.; Berova, N.; Nakanishi, K.* “UV-vis Spectral Changes in the Binding of Acyclic Diamines with a Zinc Porphyrin Tweezer” J. Ind. Chem. Soc. 1998, 75, 725-728. (Special issue for Prof. Sukh Dev’s 75th birthday)p

6. Berova, N.; Borhan, B.; Dong, J.-G.; Guo, J.; Huang, X.; Karnaukhova, E.; Kawamura, A.; Lou, J.; Matile, S.; Nakanishi, K.*; Rickman, B.; Su, J.; Tan, Q.; Zanze, I. “Solving Challenging Bioorganic Problems by Exciton Coupled CD” Pure App. Chem. 1998, 70, 377-383.p

7. Huang, X.; Borhan, B.; Matile, S.; Nakanishi, K.* “Spectroscopic Studies of PhTX Facilitated Cation Movement Across Membranes” Bioorg. Med. Chem. 1999, 7, 811-814. (Special issue in memory of Sir. Derek H. Barton)p

8. Jiang, H.; Huang, X.; Nakanishi, K.*; Berova, N.* “Nanogram Scale Absolute Configurational Assignment of Ceramides by Circular Dichroism” Tetrahedron Lett. 1999, 40, 7645-7649.p

9. Huang, X.; Nakanishi, K.*; Berova, N.* “Porphyrins and Metalloporphyrins: Versatile Circular Dichroic Reporter Groups for Structural Studies” Chirality 2000, 12, 237-255.p

10. Huang, X.; Borhan, B.; Rickman, B. H.; Berova, N.; Nakanishi, K.* “Zinc Porphyrin Tweezer in Host-Guest Complexation: Determination of Absolute Configurations of Primary Monoamines by Circular Dichroism” Chem.-Eur. J. 2000, 6, 216-224.p

11. Tsai, C.-Y.; Huang, X.; Wong, C.-H.* “Design and Synthesis of Cyclic Sialyl Lewis X Mimetics: a Remarkable Enhancement of Inhibition by Pre-organizing All Essential Functional Groups” Tetrahedron Lett. 2000, 41, 9499-9503.p

12. Huang, X.; Witte, K. L.; Bergbreiter, D. E.; Wong, C.-H.* “Homogenous Enzymatic Synthesis Using a Thermo-Responsive Water-Soluble Polymer Support” Adv. Synth. Catal. 2001, 1, 675-681.p

13. Kurtán, T.; Nesnas, N.; Li, Y.-Q.; Huang, X.; Nakanishi, K.*; Berova, N.* "Chiral Recognition by CD-Sensitive Dimeric Zinc Porphyrin Host. 1. Chiroptical Protocol for Absolute Configurational Assignments of Monoalcohols and Primary Monoamines" J. Am. Chem. Soc. 2001, 123, 5962-5973.p

14. Kozlov, I.A.; Mao, S.; Xu, Y.; Huang, X.; Lee, L.V.; Sears, P.S.; Gao, C.; Coyle, A.R.; Janda, K.D.; Wong, C-H.* "Synthesis of Solid Supported Mirror-Image Sugars: A Novel Method for Selecting Receptors for Cellular Surface Carbohydrates" ChemBioChem. 2001, 2, 741-746.p

15. Ye, X.-S.; Huang, X.; Wong, C.-H.* “Conversion of the Carboxy Group of Sialic Acid Donors to a Protected Hydroxymethyl Group Yields an Efficient Reagent for the Synthesis of the Unnatural -linkage” Chem. Commun. 2001, 974-975.p

16. Solladié-Cavallo, A.*; Marsol, C.; Pescitelli, G.; Di Bari, L.; Salvadori, P.; Huang, X.; Fujioka, N.; Berova, N.; Cao, X.; Freedman, T. B.; Nafié, L. A. “(R)-(+)- and (S)-(-)-1-(9-Phenanthryl)ethylamine: Assignment of Absolute Configuration by CD Tweezer and VCD Methods, and Difficulties Encountered with the CD Exciton Chirality Method” Eur. J. Org. Chem. 2002, 1788-1796.p

17. Huang, X.; Fujioka, N.; Pescitelli, G.; Koehn, F. E.; Williamson, R. T.; Nakanishi, K.*; Berova, N.* “Absolute Configurational Assignments of Secondary Amines by CD-Sensitive Dimeric Zinc Porphyrin Host” J. Am. Chem. Soc. 2002, 124, 10320-10335.p

18. Proni, G.; Pescitelli, G.; Huang, X.; Nakanishi, K.*; Berova, N.* “Configurational Assignment of -chiral Carboxylic Acids by Complexation to Dimeric Zn-porphyrin: Host/Guest Structure, Chiral Recognition and Circular Dichroism” Chem. Commun. 2002, 1590-1591.p

19. Zhang, Z.; Niikura, K.; Huang, X.; Wong, C.-H.* “A Strategy for the One-pot Synthesis of Sialylated Oligosaccharides” Can. J. Chem. 2002, 80, 1051-1054.p

20. Proni, G.; Pescitelli, G.; Huang, X.; Nakanishi, K.*; Berova, N.* “Magnesium Tetraaryl-porphyrin Tweezer: a Sensitive Host for Recognition of -chiral Carboxylic Acids” J. Am. Chem. Soc. 2003, 125, 12914-12927.p

21. Balaban, T. S.; Berova, N.; Drain, C. M.; Hauschild, R.; Huang, X.; Kalt, H.; Lebedkin, S.; Lehn, J.-L.; Nifaitis, F.; Pescitelli, G.; Prokhorenko, V. I.; Riedel, G.; Smeureanu, G.; Zeller, J.* “Syntheses and Energy Transfer in Multiporphyrinic Arrays Self-Assembled with Hydrogen-Bonding Recognition Groups and Comparison with Covalent Steroidal Models” Chem. Eur. J. 2007, 13, 8411-8427.p