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Publications

  1. Ghanbarpour, A.; Pinger, C.; Esmatpour Salmani, R.; Assar, Z.; Santos, E. M.; Nosrati, M.; Pawloski, K.; Spence, D.; Vasileiou, C.; Jin, X.; Borhan, B.; Geiger, J. H. "Engineering the hCRBPUU Domain-Swapped Dimer into a New Class of Protein Switches", J. Am. Chem. Soc. 2019, 141(43), 17125-17132.
  2. Ghanbarpour, A.; Nairat, M.; Nosrati, M.; Santos, E. M.; Vasileiou, C.; Dantus, M.; Borhan, B.; Geiger, J. H. "Mimicking Microbial Rhodopsin Isomerization in a Single Crystal", J. Am. Chem. Soc. 2019, 141(4), 1735-1741.
  3. Sheng, W.; Nick, S. T.; Santos, E. M.; Ding, X.; Zhang, J.; Vasileiou, C.; Geiger, J. H.; Borhan, B. "A Near-Infrared Photoswitchable Protein-Fluorophore Tag for No-Wash Live Cell Imaging", Angew. Chem. Int. Ed. Engl. 2018, 57, 14742-14746.
  4. Sheng, W.; Nairat, M.; Pawlaczyk, P. D.; Mroczka, E.; Farris, B.; Pines, E.; Geiger, J.; Borhan, B.; Dantus, M. "Ultrafast Dynamics of a "Super" Photobase", Angew. Chem. Int. Ed. Engl. 2018, 57, 14742-14746.
  5. Berbasova, T.; Nick, S. T.; Nosrati, M.; Nossoni, Z.; Santos, E. M.; Vasileiou, C.; Geiger, J. H.; Borhan, B. "A Genetically Encoded Ratiometric pH Probe: Wavelength Regulation-Inspired Design of pH Indicators", ChemBioChem 2018, 19, 1288-1295.
  6. Zhong, H. A.; Santos, E.; Vasileiou, C.; Zheng, Z.; Geiger, J. H.; Borhan, B.; Merz, K. M. "Free-Energy-Based Protein Design: Re-Engineering Cellular Retinoic Acid Binding Protein II Assisted by the Moveable-Type Approach", J. Am. Chem. Soc. 2017, 140(10), 3483-3486.
  7. Assar, Z.; Nossoni, Z.; Wang, W.; Santos, E. M.; Kramer, K.; McCormack, C.; Vasileiou, C.; Borhan, B.; Geiger, J. H. "Domain-Swapped Dimers of Intracellular Lipid-Binding Proteins: Evidence for Ordered Folding Intermediates", Structure 2016, 24(9), 1590-1598.
  8. Nosrati, M.; Berbasova, T.; Vasileiou, C.; Borhan, B.; Geiger, J. H. "A Photoisomerizing Rhodopsin Mimic Observed at Atomic Resolution", J. Am. Chem. Soc. 2016, 138(28), 81802-8808.
  9. Feng, L; Fawaz, R.; Hovde, S.; Sheng, F.; Nosrati, M.; Geiger, J. H. "Crystal Structures of Escherichia coli Branching Enzyme in Complex with Cyclodextrins", Acta Crystallographica D Structural Biology, 2016, 72, 641-647.
  10. Berbasova, T.; Santos, E. M.; Nosrati, M.; Vasileiou, C.; Geiger, J. H.; Borhan, B. "Light-Activated Reversible Imine Isomerization: Towards a Photochromic Protein Switch", ChemBioChem 2016, 17(5), 407-414.
  11. Burton, Z. F.; Opron, K.; Wei, G.; Geiger, J. H. "A Model for Genesis of Trancription Systems", Trancription 2016, 7(1), 1-13.
  12. Feng, L.; Fawaz, R.; Hovde, S.; Gilbert, L.; Chiou, J.; Geiger, J. H. "Crystal Structure of Escherichia coli Branching Enzyme in Complex with Linear Oligosaccharides", Biochemistry 2015, 54(40), 6207-6218.
  13. Thomburg, C. K.; Wortas-Strom, S.; Nosrati. M.; Geiger, J. H.; Walker, K. D. "Kinetically and Crystallographically Guided Mutations of a Benzoate CoA Ligase (BadA) Elucidate Mechanism and Expand Substrate Permissivity", Biochemistry 2015, 54(40), 6230-6242.
  14. Yapici, I.; Lee, K. S. S.; Berbasova, T.; Nosrati, M.; Jia, X.; Vasileiou, C.; Wang, W.; Santos, E. M.; Geiger, J. H.; Borhan, B. ""Turn-On" Protein Fluorescence: In Situ Formation of Cyanine Dyes", J. Am. Chem. Soc. 2015, 137(3), 1073-1080.
  15. Nossoni, Z.; Assar, Z.; Yapici, I.; Nosrati, M.; Wang, W.; Berbasova, T.; Vasileiou, C.; Borhan, B.; Geiger, J. H. “Structures of Holo Wild-Type Human Cellular Retinol-Binding Protein II (hCRBPII) Bound to Retinol and Retinal”, Acta Crystallographica D Biol Crystaloogr., 2014, D70, 3226-3232.
  16. Wang, W.; Geiger, J. H.; Borhan, B. “the photochemical determinants of color vision” Bioassays, 2014, 36(1), 65-74.
  17. Huntress, M. M.; Gozem, S.; Malley, K. R.; Jailaubekov, A. E.; Vasileiou, C.; Vengris, M.; Geiger, J. H.; Borhan, B.; Shapiro, I.; Larsen, D. S.; Olivucci, M. “Toward An Understanding Of The Retinal Chromophore In Rhodopsin Mimics” J. Phys. Chem. B 2013, 117, 10053-10070.
  18. Berbasova, T; Vasileiou, C.; Nosrati, M.; Wang, W.; Stephen Lee, K.-S.; Yapici, I.; Geiger, J.H.; Borhan, B. "Rational Design of Colorimetric pH sensor from a soluble retinoic acid chaperone" J. Am. Chem. Soc. 2013, 135(43), 16111-16119.
  19. Wang, W.; Nossoni, Z.; Berbasova, T.; Watson, C. T.; Yapici, I.; Lee, K. S. S.; Vasileiou, C.; Geiger, J. H.; Borhan, B. "Tuning the Electronic Absorption of Protein-Embedded All-trans-Retinal", Science, 2012, 338, 1340-1343.
  20. Bhattacharjee, S.; Dong, J .; Ma, Y.; Hovde, S.; Geiger, J. H.; Baker, G. L.; Bruening, M. L. "Formation of High-Capacity Protein-Adsorbing Membranes through Simple Adsorption of Poly(acrylic acid)-Containing Films at Low pH", Langmuir 2012, 28(17), 6885-6892.
  21. Lee, K. S. S.; Berbasova, T.; Vasileiou, C.; Jia, X.; Wang, W.; Choi, Y.; Nossoni, F.; Geiger, J. H.; Borhan, B. "Probing Wavelength Regulation with an Engineered Mimic and a C15-Retinal Analogue", Chem.Plus.Chem. 2012, 77(4), 273-276.
  22. Anuraj, N.; Bhattacharjee, S.; Geiger, J. H.; Baker, G. L.; Bruening, M. L. "An all-Aqueous Route to Polymer Brush-Modified Membranes with Remarkable Permeabilities and Protein Capture Rates", J. Membr. Sci. 2012, 389, 117-125.
  23. Strom, S.; Wanninauake, U.; Ratnayake, N. D.; Walker, K. D.; Geiger, J. H. "Insights into the Mechanistic Pathway of the Pantoea agglomerans Phenylalanine Aminomutase", Ang. Chem. Int. Ed. 2012, 51(12), 2898-2902.
  24. Ratnayake, N. D.; Wanninauake, U.; Geiger, J. H.; Walker, K. D. "Stereochemistry and Mechanism of a Microbial Phenylalanine Aminomutase", J. Am. Chem. Soc. 2011, 133(22), 8531-8533.
  25. Xu, F.; Geiger, J. H.; Baker, G. L.; Bruening, M. L. "Polymer Brush-Modified Nanoparticles for His-Tagged Protein Purification", Langmuir 2011, 27(6), 3106-3112.
  26. Cnudde, S. E.; Prorok, M.; Jia, X.; Castellino, F. J.; Geiger, J. H. "The crystal structure of a calcium-bound con-G[Q6A] peptide reveals a novel metal-dependent helical trimer", J. Biol. Inorg. Chem. 2011, 16(2), 257-266.
  27. Cnudde, S. E.; Prorok, M.; Castellino, F. J.; Geiger, J. H. “Metal ion determinants of conantokin dimerization as revealed in the X-ray crystallographic structure of the Cd2+/Mg2+-con-T[K7 gamma] complex”, J. Biol. Inorg. Chem. 2010, 15(5), 667-675.
  28. Jain, P.; Vyas, M. K.; Geiger, J. H.; Baker, G. L.; Bruening, M. L. “Protein purification with polymeric affinity membranes containing functionalized poly(acid) brushes”, Biomacromolecules 2010, 11(4), 1019-1026.
  29. Wang, M.; Zajicek, J.; Geiger, J. H.; Prorok, M.; Castellino, F. J. “Solution structure of the complex of VEK-30 and plasminogen kringle 2”, J. Struct. Biol. 2010, 169(3), 349-359.
  30. Vasileiou, C.; Wang, W.; Jia, X.; Lee, K. S. S.; Watson, C.; Geiger, J. H.; Borhan, B. “Elucidating the exact role of engineered CRABPII residues for the formation of a retinal protonated Schiff base”, Proteins-structure function and bioinformatics 2009, 77(4), 812-822.
  31. Sheng, F.; Yep, A.; Feng, L.; Preiss ,J.; Geiger, J. H. “Oligosaccharide binding in Escherichia coli glycogen synthase”, Biochemistry 2009, 48(42), 10089-10097.
  32. Sheng, Z. Y.; Liang, Z.; Geiger, J. H.; Prorok, M.; Castellino F. J. “The selectivity of conantokin-G for ion channel inhibition of NR2B subunit-containing NMDA receptors is regulated by amino acid residues in the S2 region of NR2B”, Neuropharmacology 2009, 57(2), 127-136.
  33. Sheng, F.; Jia, X.; Yep, A.; Preiss, J.; Geiger, J .H. “The crystal structure of the open and catalytically competent closed conformation of Escherichia coli glycogen synthase”, J. Biol. Chem. 2009, 284(26), 177796-17807.
  34. Vasileiou, C.; Lee, K. S. S.; Crist, R. M.; Vaezeslami, S.; Goins, S. A.; Geiger, J. H.; Borhan, B. “Dissection of the critical binding determinants of cellular retinoic acid binding protein II by mutagenesis and fluorescence binding assay”, Proteins-structure function and bioinformatics 2009, 76(2), 281-290.
  35. Vaezeslami, S.; Jia, X.; Vasileiou, C.; Borhan, B.; Geiger, J. H. “Structural analysis of site-directed mutants of cellular retinoic acid-binding protein II addresses the relationship between structural integrity and ligand binding”, Acta Cryst. D.-Biological Crystallography 2008, 64, 1228-1239.
  36. Fu, Q. H.; Figuera-Losada, M.; Pioplis, V. A.; Cnudde, S.; Geiger, J. H.; Prorok, M.; Castellino, F. J. “The lack of binding of VEK-30, an internal peptide from the group a streptococcal m-like protein, PAM, to murine plasminogen is due to two amino acid replacements in the plasminogen kringle-2 domain”, J. Biol. Chem. 2008, 283(3), 1580-1587.
  37. Vasileiou, C.; Vaezeslami, S.; Crist, R. M.; Rabago-Smith M.; Geiger, J. H.; Borhan, B. “Protein design: Reengineering Cellular Retinoic Acid Binding Protein II into a rhodopsin protein mimic”, J. Am. Chem. Soc. 2007, 129(19), 6140-6148.
  38.  Dai, Q.; Sheng, Z.; Geiger, J. H.; Castellino, F. J.; Prorok, M. “Helix-helix interactions between homo- and heterodimeric gamma-carboxyglutamate-containing conantokin peptides and their derivatives”, J. Biol. Chem. 2007, 282(17), 12641-12649.
  39. Cnudde, S. E.; Prorok, M.; Dai, Q.; Castellino, F. J.; Geiger, J. H. “The crystal structures of the calcium-bound con-G and con-T[K7 gamma] dimeric peptides demonstrate a metal-dependent helix-forming motif”, J. Am. Chem. Soc. 2007, 129(6); 1586-1593.
  40. Jin, X.; Geiger, J. H. “The structure and mechanism of myo-inositol-1-phosphate synthase”, Subcell Biochem 2006, 39, 157-180.
  41. Vaezeslami, S.; Mathes, E.; Vasileiou, C.; Borhan, B.; Geiger, J. H. “The structure of apo-wild-type cellular retinoic acid binding protein II at 1.4 a and its relationship to ligand binding and nuclear translocation”, J. Mol. Biol. 2006, 363(3), 687-701.
  42. Jawdekar, G. W.; Hanzlowsky, A.; Hovde, S. L.; Jelencic, B.; Feig, M.; Geiger, J. H.; Henry, R. W. “The unorthodox SNAP50 zinc finger domain contributes to cooperative promoter recognition by human SNP(C)”, J. Biol. Chem. 2006, 281(41), 31050-31060.
  43. Cnudde, S. E.; Prorok, M.; Castellino, F. J.; Geiger, J. H. “X-ray crystallographic structure of the angiogenesis inhibitor, angiostatin, bound to a peptide from the group A streptococcal surface protein PAM”, Biochemistry 2006, 45(37), 11052-11060.
  44. Hanzlowsky, A.; Jelencic, B.; Jawdekar, G. W.; Hinkley, C. S.; Geiger, J. H.; Henry, R. W. “Co-expression of multiple subunits enables recombinant SNAP(C) assembly and function for transcription by human RNA polymerases II and III”, Protein expression and purification 2006, 48(2), 215-223.
  45. Crist, R. M.; Vasileiou, C.; Rabago-Smith, M.; Geiger, J. H.; Borhan, B. “Engineering a rhodopsin protein mimic”, J. Am. Chem. Soc. 2006, 128(14), 4522-4523.
  46. Shi, Y. H.; Vaden, D. L.; Ju, S. L.; Ding, D. B.; Geiger, J. H.; Greenberg, M. L. “Genetic perturbation of glycolysis results in inhibition of de novo inositol biosynthesis”, J. Biol. Chem. 2005, 280(51), 41805-41810.
  47. Jin, X.; Ballicora, M. A.; Preiss, J.; Geiger, J. H. “Crystal structure of potato tuber ADP-glucose pyrophosphorylase”, EMBO J. 2005, 24(4), 694-704.
  48. Jin, X.; Foley, K. M.; Geiger, J. H. “The structure of the 1L – myo – inositol -1-phosphate synthase – NAD (+) -2 deoxy-D-glucitol 6-(E)-vinylhomo phosphonate complex demands a revision of the enzyme mechanism”, J. Biol. Chem. 2004, 279(14), 13889-13895.
  49. Geiger, J. H. “Sugar tongs get a grip on the starch granule in barley alpha-amylase 1”, Structure 2003, 11(8), 903-904.
  50. Jin, X. S.; Geiger, J. H. “Structures of NAD(+)- and NADH-bound 1-L-myo-inositol 1-phosphate synthase”, Acta Cryst. D.-Biological Crystallography 2003, 59, 1154-1164.
  51. Nedialkov, Y. A.; Gong, X. Q.; Hovde, S. L.; Yamagushi, Y.; Handa, H.; Geiger, J. H.; Yan, H. G.; Burton, Z. F. “NTP-driven translocation by human RNA polymerase II”, J. Biol. Chem. 2003, 278(20), 18303-18312.
  52. Abad, M. C.; Binderup, K.; Rios-Steiner, J.; Arni, R. K.; Preiss, J.; Geiger, J. H. “The X-ray crystallographic structure of Escherichia coli branching enzyme”, J. Biol. Chem. 2002, 277(44), 42164-42170.
  53. Abad M. C.; Arni, R. K.; Grella, D. K.; Castellino, F. J.; Tulinsky, A.; Geiger, J. H. “The X-ray crystallographic structure of the angiogenesis inhibitor angiostatin”, J. Bol. Biol. 2002, 318(4), 1009-1017.
  54. Hovde, S.; Brooks, A.; Strong, K.; Geiger, J. H. “Crystallization of the Oct-1/SNAP190 peptide/DNA complex”, Acta Cryst. D. - Biological Crystallography 2002, 58, 511-512.
  55. Stein, A. J.; Geiger, J. H. “The crystal structure and mechanism of 1-L-myo inositol-1 phosphate synthase”, J. Biol. Chem. 2002, 277(11), 9484-9491.
  56. Abad, M. C.; Binderup, K.; Preiss, J.; Geiger, J. H. “Crystallization and preliminary X-ray diffraction studies of Escherichia coli branching enzyme”, Acta Cryst. D.-Biological Crystallography 2002, 58, 359-361.
  57. Hovde, S.; Abate-Shen, C.; Geiger, J. H. “Crystal structure of the Msx-1 homeodomain/DNA complex”, Biochemistry 2001, 40(40), 12013-12021.
  58. Stein, A. J.; Geiger, J. H. “Structural studies of MIP synthase”, Acta Cryst. D.-Biological Crystallography 2002, 56, 348-350.
  59. DeWees, S.; Geiger, J. H. “Structural studies of the Msx-1 homodomain-DNA complex I”, Acta Cryst. D.-Biological Crystallography 1999, 55, 2039-2040.