Preparation of Amines

Five amine syntheses are outlined below. In each reaction box enter a single letter designating the best reagent and conditions selected from the list at the bottom of the page.


1.

   First Step

Second Step


2.

  
  First Step

Second Step
  Third Step


3.

   First Step

Second Step


4.

   First Step

Second Step


5.

  
  First Step
Second Step

  Third Step
  Fourth Step

   

A. (i) LiAlH4 in ether
      (ii) H2O & base 		B. C2H5NH2 (cat. H(+)) C. NaCN in alcohol D. H2 & Ni catalyst
or H2 & Pd catalyst		 E. NaN3 in alcohol
F. (CH3CO)2O & pyridine G. C2H5Br H. cyclohexanone (cat. H(+)) I. 2 CH3I & pyridine J. KOH in H2O

This script written by William Reusch, Dept. of Chemistry, Michigan State University. Please send comments and corrections to whreusch@pilot.msu.edu.