Jetze J. P. M. Tepe

Research

Total Synthesis of Natural Products
Marine sponge metabolites represent a highly diverse and structurally complex natural library of compounds with remarkable biological and medicinal properties. Students in the group will develop novel heterocyclic methodologies enable the efficient synthesis of natural products.
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Chemical Biology
The structural diversity of marine sponge metabolites makes them ideal as tools to discover novel targets and mechanisms. The main cellular target of interest in the "proteasome". In our chemical biology lab, students will unravel the biological properties of marine sponge metabolites and determine their use as therapeutic leads or biochemical tools.
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Medicinal Chemistry
Our lab develops new chemical methodologies to mimic the diverse structural features found in natural products with the goal to capture their unique biological properties in drug-like scaffolds. Students in the lab with synthesize and test the new scaffolds in order to optimize the natural product mimics for potency, selectivity, ADME, PK and PD properties. Current programs are focused on novel therapeutics for multiple myeloma, neurodegenerative diseases, and tuberculosis.
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Current Research Support

NIH R01 AG066223-01A1 (PI, Tepe)
Title: Small molecule induced proteolytic destruction of intrinsically disordered proteins

09/15/19-05/31/23

NIH-IGNITE 1R61NS111347-01A1 (PI, Tepe)
Title: Development of cellular HTS for 20S proteasome enhancers

12/01/19-11/31/22

NIH R21 AG061306-01 (PI, Tepe)
Title: Multiparameter optimization of new phenothiazines for proteasome activation

12/01/19-11/31/21

International Myeloma Foundation (PI, Tepe)
Title: Targeting c-Myc degradation to treat myeloma

01/01/19-12/31/19