Spence Group Research

Defining New Roles and Properties of the Red Blood Cell in Human Health

Publications 2009-2010

Integrative Biology

The Dual Nature of Extracellular ATP as a Concentration-dependent Platelet P2X1 Agonist and Antagonist

Vol 1, pp 655-663, 2009

The Review of Diabetic Studies

A Molecular Level Understanding of Zinc Activation of C-peptide and its Effects on Cellular Communication in the Bloodstream

Vol 6, pp 148-158, 2009

Molecular Biosystems

Zinc-activated C-peptide Resistance to the Type 2 Diabetic Erythrocyte is Associated with Hyperglycemia-induced Phosphaditylserine Externalization and Reversed by Metformin

Vol 5, pp 1157-1162, 2009

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Metallomics

A Perspective on the Role of Metals in Diabetes:  Past Findings and Possible Future Findings

Vol 1, pp 32-41, 2009

Analyst

A Microfluidic Technique for Monitoring Bloodstream Analytes Indicative of C-peptide Resistance in Type 2 Diabetes

Vol 134, pp 188-193, 2009

Analytical Chemistry

Personalized Metabolic Assessment of Erythrocytes using Microfluidic Delivery to an Array of Luminescent Wells

Vol 81, pp 3102-3108, 2009

European Journal of Pharmacology

Hydroxyurea Stimulates the Release of ATP from Rabbit Erythrocytes through an Increase in Calcium and Nitric Oxide Production

In press, 2010

Analytical Chemistry

Direct Plate Reader Measurement of Nitric Oxide Released from Hypoxic Erythrocytes Flowing through a Microfluidic Device

Pure and Applied Chemistry

Use of the Red Blood Cell as a Simple Target and Diagnostic by Manipulating and Monitoring its Ability to Release Adenosine Triphosphate (ATP)

Analytical and Bioanalytical Chemistry

Evaluating the Effects of Estradiol on Endothelial Nitric Oxide Stimulated by Erythrocyte-derived ATP using a Microfluidic Approach

Analyst

Mass Spectrometric Characterization and Activity of Zinc-Activated Proinsulin C-peptide and C-peptide Mutants

In press, 2010

Vol 8, pp 1623-1634, 2010

Vol 397, pp 3369-3375, 2010

Vol 135, pp 278-288, 2010