Publications
2013
Yin, J.; Comellas-Aragones, M.; Chowdhury, S.; Bentley, P.; Kaczanowska, K.; BenMohamed, L.; Gildersleeve, J. C.; Finn, M.G.; Huang, X. Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids, ACS Chem. Biol., 2013, in press
El-dakdouki, M.; Puré, E.; Huang, X. Development of Drug Loaded Nanoparticles for Tumor Targeting. Part 2: Enhancement of Tumor Penetration Through Receptor Mediated Transcytosis in 3D Tumor Models, Nanoscale, 2013, in press
El-dakdouki, M.; Puré, E.; Huang, X. Development of Drug Loaded Nanoparticles for Tumor Targeting. Part 1: Synthesis, Characterization, and Biological Evaluation in 2D Cell Cultures, Nanoscale, 2013, in press
El-dakdouki, M.; El-boubbou, K.; Kamat, M.; Huang, R.; Abela, G.; Zhu, D. C.; Huang, X. CD44 Targeting Magnetic Glyconanoparticles for Atherosclerotic Plaque Imaging, Pharm. Res., 2013, in press
Kouyoumdjian, H.; Zhu, D. C.; El-Dakdouki, M. H.; Lorenz, K.; Chen, J.; Li, W.; Huang, X. Glyconanoparticle Aided Detection of β-Amyloid by Magnetic Resonance Imaging and Attenuation of β-Amyloid Induced Cytotoxicity, ACS Chem. Neurosci., 2013, ASAP
2012
Yang, B.; Yoshida, K.; Yin, Z.; Dai, H.; Kavunja, H.; El-Dakdouki, M. H.; Sungsuwan, S.; Dulaney, S. B.; Huang, X. Chemical Synthesis of Homogeneous Syndecan-1 Heparan Sulfate Glycopeptide, Angew. Chem. Int. Ed., 2012, 51, 10185-10189
Yin, Z.; Nguyen, H. G.; Chowdhury, S.; Bentley, P.; Bruckman, M. A.; Miermont, A.; Gildersleeve, J. C.; Wang, Q.; Huang, X. Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens, Bioconjugate Chem., 2012, 23, 1694-1703. NIHMSID: 396464
Huang, X. Foreword, J. Carbohydr. Chem., 2012, 31, 253-254 Foreword to the Special Issue Dedicated to the 7th Midwest Carbohydrate and Glycobiology Symposium
Sheng, J.; Xu, Y.; Dulaney, S. B.; Huang, X.; Liu, J. Uncovering a Biphasic Catalytic Mode of C5-epimerase in Heparan Sulfate Biosynthesis, J. Biol. Chem., 2012, 287, 20996-21002
Xu. Y.; Wang, Z.; Liu, R.; Bridges, A. S.; Huang, X.; Liu, J. Directing the Biological Activities of Heparan Sulfate Oligosaccharides Using a Chemoenzymatic Approach, Glycobiology, 2012, 22, 96-106
Sun, B.; Yang, B.; Huang, X. Total Synthesis of the Aminopropyl Functionalized Ganglioside GM1, Sci. China Chem., 2012, 55, 31-35
Li, H.; El-dakdouki, M.H.; Zhu, D. C.; Abela, G. S.; Huang, X.; Synthesis of b-cyclodextrin Conjugated Superparamagnetic Iron Oxide Nanoparticles for Detection of Cholesterol Crystals, Chem. Commun., 2012, 48, 3385-3387 (This article was highlighted as the back cover of the issue)
El-dakdouki, M.H.; Zhu, D. C.; El-Boubbou, K.; Kamat, M.; Chen, J.; Li, W.; Huang, X. Development of Multifunctional Hyaluronic Acid Coated Nanoparticles: Targeted Imaging and Drug Delivery to Cancer Cells in vitro, Biomacromolecules, 2012, 13, 1144-1151
Dulaney, S. B.; Huang, X. Recent Strategies in Heparin/heparan Sulfate Oligosaccharide Synthesis: 2000 – present, Adv. Carbohydr. Chem. Biochem., 2012, 67, 95-136 (invited review)
Yin, Z.; Huang, X. Recent Development in Carbohydrate Based Anti-cancer Vaccines, J. Carbohydr. Chem., 2012, 31, 143-186
2011
El-dakdouki, M.H.; El-Boubbou, K.; Zhu, D. C.; Huang, X. A Simple Method for the Synthesis of Hyaluronic Acid Coated Magnetic Nanoparticles for Highly Efficient Cell Labeling and in vivo Imaging, RSC Adv., 2011, 1, 1449-1452
Yin, Z.; Dulaney, S.; Tiruchinapally, G.; Yang, B.; Huang, X. A Facile Method for Oxidation of Primary Alcohols to Carboxylic Acids in Carbohydrate Synthesis, Carbohydrate Chemistry, Proven Synthetic Methods, Volume 2, 2011, in press
El-dakdouki, M.H.; Huang, X. Biological Applications of Hyaluronic Acid Functionalized Nanomaterials, in Glyco-Nanotechnology as a Bridge to New Medicines, ACS symposium series, Editors: Huang, X.; Barchi, J. 2011, 181-213
Tiruchinapally, G.; Yin, Z.; El-dakdouki, M.H.; Wang, Z.; Huang, X.
Divergent Heparin Oligosaccharide Synthesis with Pre-installed Sulfate
Esters, Chem. Eur. J., 2011, 17, 10106 – 10112
El-boubbou, K.; Huang, X. Glyco-Nanomaterials: Translating Insights
from the “Sugar-code” to Biomedical Applications,
Curr. Med. Chem. , 2011, 18, 2060-2078
Deng, C. X.; Huang, X. Improved Outcome of Targeted Delivery of
Chemotherapy Drug to the Brain using a Combined Strategy of Ultrasound,
Magnetic Targeting, and Drug Loaded Nanoparticles,
Therapeutic Delivery , 2011, 2, 137–141
Li, X.; Zhou, H.; Yang, L.; Du, G.; Pai-Panandiker, A. S.; Huang, X.;
Yan, B. Enhancement of Cell Recognition in vitro by Dual-ligand Cancer
Targeting Gold Nanoparticles,
Biomaterials, 2011, 232, 2540-2545
Wasonga, G.; Zeng, Y.; Huang, X.
Pre-activation Based Stereoselective Glycosylations: Stereochemical
Control by Additives and Solvent,
Sci. China Chem., 2011, 54, 1, 66-73
2010
Kamat, M.; El-Boubbou, K.; Zhu, D.; Lansdell, T.; Lu, X.; Li, W.;
Huang, X.
Hyaluronic Acid Immobilized Magnetic Nanoparticles for Active Targeting
and Imaging of Macrophages,
Bioconjugate Chem., 2010, 21, 11, 2128–2135
Wang, Z.; Xu, Y.;
Yang, B.; Tiruchinapally,
G.; Sun, B.; Liu, R.; Dulaney, S.; Liu, J.; Huang, X.
Pre-activation-Based One-pot Combinatorial Synthesis of Heparin-like
Hexasaccharides for the Analysis of Heparin–Protein Interactions,
Chem. Eur. J., 2010, 16, 28, 8365-8375. (This article was rated by
the reviewers as VIP publication)
El-Boubbou,
K.;
Zhu,
D.;
Vasileiou,
C.;
Borhan,
B.;
Prosperi,
D.;
Li,
W.;
Huang,
X.
Magnetic
Magnetic
Glyco-Nanoparticles:
A
Tool
To
Detect,
Differentiate,
and
Unlock
the
Glyco-Codes
of
Cancer
via
Magnetic
Resonance
Imaging,
J. Am. Chem. Soc., 2010,
132, 12, 4490-4499.
Yang,
B.;
Jing,
Y.;
Huang,
X.
Fluorous
Assisted
One-pot
Oligosaccharide
Synthesis. Eur. J. Org. Chem.,
2010,
7,
1290–1298.
Wang,
Y.;
El-Boubbou,
K.;
Kouyoumdjian,
H.;
Sun,
B.; Huang, X.; Zeng, X. Lipoic Acid Carbohydrate Conjugates, a New
Class of Agents for Controlling Nonspecific Adsorption of Blood Serum
at Bio-interfaces for Biosensor and Biomedical Applications,
Langmuir, 2010, 26, 4119-4125.
2009
Lu, X.;
Kamat, M. N.; Huang, L.; Huang, X.
Chemical Synthesis of a Hyaluronic Acid Decasaccharide, J. Org.
Chem., 2009, 74, 7608-7617 (JOC Featured article)
Li,
X.;
Huang,
L.;
Hu,
X.;
Huang,
X.
Thio-arylglycosides
with
Various
Aglycon
Para-Substituents,
a
Useful
Tool
for
Mechanistic
Investigation
of
Chemical
Glycosylations,
Org. Biomol. Chem., 2009, 7, 117-127.
2008
Zeng, Y.;
Wang, Z.; Whitfield, D., Huang, X.
Installation of Electron Donating Protective Groups, a Strategy for
Glycosylating Unreactive Thioglycosyl Acceptors using the
Pre-activation Based Glycosylation Strategy, J. Org. Chem.,
2008, 73, 7952-7962.
Wang, Z.; Huang, X. p-Toluenesulfenyl Chloride
Electronic Encyclopedia of Reagents in Organic Synthesis, 2008.
Sun,
B.;
Srivinasan,
B.;
Huang,
X.
Pre-activation
Based
One-pot
Synthesis
of
an
α-(2,3)-Sialylated
Core-Fucosylated
Complex
Type
Bi-antennary
N-Glycan
Dodecasaccharide,
Chem. Eur. J., 2008, 14, 7072-7081
Wang,
Z.;
Gilbert,
M.;
Eguchi,
H.;
Yu,
H.;
Cheng,
J.;
Muthana,
S.;
Zhou,
L.;
Wang,
P.
G.;
Chen,
X.;
Huang,
X.
Chemoenzymatic
Syntheses
of
Tumor-Associated
Carbohydrate
Antigen
Globo-H
and
Stage-Specific
Embryonic
Antigen
4,
Adv. Synth. Catal.,
2008,
350,
1717-1728.
Miermont,
A.;
Barnhill,
H.;
Strable,
E.;
Lu,
X.;
Wall,
K.
A.;
Wang,
Q.;
Finn,
M.
G.;
Huang,
X.
Cowpea
Mosaic
Virus
Capsid,
a
Promising
Carrier
towards
the
Development
of
Carbohydrate
Based
Anti-tumor
Vaccines,
Chem. Eur. J., 2008, 14,
4939-4947.
Huang, L.; Lu, X.; Huang, X. Chemical
Syntheses of Hyaluronic Acid Oligosaccharides, in Chemical Glycobiology
II: Glycopharmaceuticals and Glycovaccines, ACS symposium series, 2008.
Srinivasan,
B.;
Huang,
X.
Functionalization
of
Magnetic
Nanoparticles
with
Organic
Molecules:
Loading
Level
Determination
and
Evaluation
of
Linker
Length
Effect
on
Immobilization,
Chirality , 2008, 20, 265-277. (Special issue dedicated to
Prof. Nina Berova)
2007
El-Boubbou,
K.;
Gruden,
C.;
Huang,
X.
Magnetic
Glyco-nanoparticles:
A
Unique
Tool
for
Rapid
Pathogen
Detection,
De-contamination
and
Strain
Differentiation,
J. Am.
Chem. Soc., 2007, 129, 13392-13393.
Miermont,
A.; Zeng, Y.; Jing, Y.; Ye, X.-S.;
Huang, X. Syntheses of LewisX and Dimeric LewisX: Construction of
Branched Oligosaccharides by a Combination of Pre-activation and
Reactivity Based Chemoselective One-Pot Glycosylations, J. Org.
Chem. , 2007, 72, 8958-8961.
Teumelsan,
N.; Huang, X. Synthesis of
Branched Oligomannans and an Unusual Stereochemical Observation,
J. Org. Chem. , 2007, 72, 8976-8979.
Wang, Z.;
Zhou, L.; El-boubbou, K.; Ye,
X.-S.; Huang, X. Four Component One-Pot Synthesis of the
Tumor-Associated Carbohydrate Antigen Globo-H Based on Preactivation of
Thioglycoside Donors. J. Org. Chem. , 2007, 72, 6409-6420.
Wang, Z.; Huang, X. Strategies in
Oligosaccharide Synthesis in Comprehensive Glycoscience. From Chemistry
to Systems Biology 2007, Editor: J. P. Kamerling, Elsevier, p379-413.
Huang,
L.;
Huang,
X.
Highly
Efficient
Syntheses
of
Hyaluronan
Oligosaccharides,
Chem. Eur. J.
2007, 13, 529-540.
2006
Wang,
C.;
Wang,
H.;
Huang,
X.;
Zhang,
L.-H.;
Ye,
X.-S.
Benzenesulfinyl
Morpholine:
A
New
Promoter
for
One-Pot
Oligosaccharide
Synthesis
Using
Thioglycosides
by
Pre-Activation
Strategy,
Synlett 2006, 2846-2850.
Huang,
L.;
Teumelsan,
N.;
Huang,
X.
A
Facile
Method
for
Oxidation
of
Primary
Alcohols
to
Carboxylic
Acids
and
Its
Application
in
Glycosaminoglycan
Syntheses,
Chem. Eur. J.
2006, 12, 5246-5252.
Huang,
L.;
Wang,
Z.;
Li,
X.;
Huang,
X.
Iterative
One-Pot
Synthesis
of
Chitotetraose,
Carbohydr. Res.
2006, 341, 1669-1679.
2005
Huang, L.; Huang, X. Methyl triflate,
Electronic Encyclopedia of Reagents in Organic Synthesis, 2005.
2004
Wang, Y.;
Huang, X.; Zhang, L.-H.; Ye, X.-S.
A Four-Component One-Pot Synthesis of a-Gal Pentasaccharide Org.
Lett. 2004, 6, 4415-4417.
Huang, X. Mercuric Bromide, Electronic
Encyclopedia of Reagents in Organic Synthesis, 2004, RN00383.
Huang,
X.;
Huang,
L.;
Wang,
H.;
Ye,
X.-S.
Iterative
One-Pot
Oligosaccharide
Synthesis,
Angew. Chem. Int. Ed.
2004, 5221-5224.
Huang,
L.;
Wang,
Z.;
Huang,
X.
One-pot
Oligosaccharide
Synthesis:
Reactivity
Tuning
by
Post-synthetic
Modification
of
Aglycon,
Chem. Commun. 2004, 1960-1961.
Jing,
Y.;
Huang,
X.
Fluorous
Thiols
in
Oligosaccharide
Synthesis,
Tetrahedron Lett. 2004, 45,
4615-4618
