Publications

2017

Kavunja, H.; Lang, S.; Sungsuwan, S.; Yin, Z.; Huang, X.* “Delivery of Foreign Cytotoxic T-lymphocyte Epitope to Tumor Tissues for Effective Antitumor Immunotherapy against Pre-established Solid Tumor” Cancer Immunol. Immunother. 2017, 66, 451-460.

2016

Thapa, R.*; Gorski, J.; Bogedin, A.; Maywood, M.; Clement, C.; Hossaini-Nasr, S.; Hanna, D.; Huang, X.; Roth, B. J.; Madlambayan, G.; Wilson, G. D. “Hyaluronan-mediated ferric oxide nanoparticles causes apoptosis of CD44 expressing head and neck squamous cell carcinoma cells” Int. J. Cancer Ther. Oncol. 2016, 4, 424.

Haro, M.; Littrell, C.; Yin, Z.; Huang, X.; Haas, K.* "PD-1 Suppresses Development of Humoral Responses That Protect against Tn-Bearing Tumors" Cancer Immunology Research 2016, 4, 1-11.

Li, Y.; Humphries, B.; Wang, Z.; Lang, S.; Huang, X.; Xiao, H; Jiang, Y.; Yang, C.* "Complex Coacervation-Integrated Hybrid Nanoparticles Increase Plasmid DNA Delivery Efficiency in vivo" ACS Appl. Mater. Interfaces 2016, 8, 30735-30746

Yang, W.; Yoshida, K; Yang, B.; Huang, X.* "Obstacles and solutions for chemical synthesis of syndecan-3 (53–62) glycopeptides with two heparan sulfate chains" Carbohydrate Res. 2016, 435, 180-194.

Yang,W.;Ramadan, S.;Yang, B.;Yoshida, K; Huang, X.* "Homoserine as an Aspartic Acid Precursor for Synthesis of Proteoglycan Glycopeptide Containing Aspartic Acid and Sulfated Glycan Chain" J. Org. Chem 2016,81, 12052-12059

Ramadan, S.; Yang, W.; Huang, X.* “Synthesis towards Heparan Sulfate Glycopeptides and Proteoglycans” in Chemical Biology of Glycoproteins, Royal Society of Chemistry; Editor: Zhongping Tan, Lai-xi Wang; 2017,209-232.

Yang, B.; Yoshida, K.; Huang, X.*; "strategies for one-pot synthesis of oligosaccharides in glycochemical synthesis: strategies and applications", Wiley-Blackwell; Editor: Shang-cheng Hung,2016,155-188.

Qin, Q.; Yin, Z.; Haas, K. M.; Huang, X.* “Valency and Density Matter: the Impacts of Immunogen Structures on Early B Cell Activation and Antibody Generation against a Tumor Associated Carbohydrate Antigen” Biomaterials 2016, 101, 189-198.

Guo, R.; Gaffney, K.; Yang, Z.; Kim, M.; Sungsuwan, S.; Huang, X.; Hubbell, W.; Hong, H.* “Steric Trapping Reveals a Cooperativity Network in the Intramembrane Protease GlpG under Native Condition” Nat. Chem. Biol. 2016, 12, 353–360.

Yin, Z.; Dulaney, S.: McKay, C. S.; Baniel, C.; Kaczanowska, K.; Ramadan, S.; Finn, M. G.; Huang, X.* “Chemical Synthesis of GM2 Glycans, Bioconjugation with Bacteriophage Qβ and the Induction of Anti-Cancer Antibodies” ChemBiochem. 2016, 17, 174-180.

2015

Thapa, R.;* Galoforo, S.; Kandel, S. M.; El-dakdouki, M. H.; Wilson, T. G.; Huang, X.; Roth, B. J.; Wilson, G. D. “Radiosensitizing and Hyperthermic Properties of Hyaluronan Conjugated, Dextran Coated Ferric Oxide Nanoparticles: Implications for Cancer Stem Cell Therapy” J. Nanomateirals 2015, doi:10.1155/2015/840594.

Vyas, D.;* Lopez-Hisijos, N.; Gandhi, S.; El-Dakdouki, M.; Basson, M. D.; Walsh, M. F.; Huang, X.; Vyas, A. K.; Chaturvedi, L. S. “Doxorubicin-Hyaluronan Conjugated Super-Paramagnetic Iron Oxide Nanoparticles (DOX-HA-SPION) Enhanced Cytoplasmic Uptake of Doxorubicin and Modulated Apoptosis, IL-6 Release and NF-kappaB Activity in Human MDA-MB-231 Breast Cancer Cells” J. Nanosci. Nanotechnol. 2015, 15, 6413-6422

Dulaney, S. B.; Xu, Y.; Wang, P.; Tiruchinapally, G.; Wang, Z.; Kathawa, J.; El-Dakdouki, M. H.; Yang, B.; Liu, J.; Huang, X.* “Divergent Synthesis of Heparan Sulfate Oligosaccharides” J. Org. Chem. . 2015, 80, 12265-12279.

Sungsuwan, S.; Yin, Z.; Huang, X.* “Lipopeptide Coated Iron Oxide Nanoparticles as Potential Glyco-Conjugate Based Synthetic Anti-Cancer Vaccines” ACS Appl. Mater. Interface 2015, 7, 17535−17544.

Yin, Z.; Wright, W. S.; McKay, C.; Baniel, C.; Kaczanowska, K.; Bentley, P.; Gildersleeve, J. C.; Finn, M. G.; BenMohamed, L.; Huang, X.* “Significant Impact of Immunogen Design on the Diversity of Antibodies Generated by Carbohydrate-based Anti-cancer Vaccine” ACS Chem. Biol., 2015, 10 (10), 2364–2372

Lu, X.; Huang, X.* “Design and Syntheses of Hyaluronan Oligosaccharide Conjugates as Inhibitors of CD44-Hyaluronan Binding” Glycoconjugate J. 2015, 32,549-556(special issue dedicated to Chemical Glycobiology).

Zhou, W.; Hsieh, P.-H., Xu, Y.; Huang, X., Liu, J.* “Design and Synthesis of Active Heparan Sulfate-based Probes” Chem. Commun. 2015, 51, 11019-11021.

Kouyoumdjian, H.; Huang, X.* “Sialic Acid Modified Nanoparticles for β-Amyloid Studies” inCarbohydrate Nanotechnology, Wiley; Editor: Keith Stine; 2015, (invited chapter)

Yin, Z.; Huang, X.* “Boosting Humoral Immune Responses to Tumor Associated Carbohydrate Antigens with Virus-like Particles” in Carbohydrates in Drug Design and Discovery, Royal Society of Chemistry, UK; Editor: Jesus Jimenez-Barbero; 2015, 132-149 (invited chapter). 10.1039/9781849739993

Kavunja, H.; Voss, P. G.; Wang, J.;* Huang, X.* “Identification of Lectins from Metastatic Cancer Cells through Magnetic Glyco-nanoparticles” Israel J. Chem. 2015, 55, 423-436. (Special issue dedicated to Dr. Chi-Huey Wong’s Wolf Prize).

Wang, P.; Kouyoumdjian, H.; Zhu, D. C.; Huang, X.* Heparin Nanoparticles for β Amyloid Binding and Mitigation of β Amyloid Associated Cytotoxicity, Carbohydr. Res. 2015, 405, 110-114. (Special issue dedicated to glyco-nanomaterials). PMCID: PMC4314519.

2014

Wang, P.; Nilsson, J.; Brinkmalm, G.; Larson, G.*; Huang, X.* Synthesis and Structural Determination of Amyloid-β (1-15) Glycopeptide, a New Biomarker for Alzheimer’s Disease Chem. Commun. 2014,50,15067-15070

Qin, Q.; Yin, Z.; Bentley, P.; Huang, X.* Carbohydrate Antigen Delivery by Water Soluble Copolymers as Potential Anti-cancer Vaccines, Med. Chem. Commun. 2014, 5, 1126-1129 (This article was highlighted as the inside cover of the issue)

Yoshida, K.; Yang, B.; Yang, W.; Zhang, Z.; Zhang, J. Huang, X.* Chemical Synthesis of Human Syndecan-3 Glycopeptides Bearing Two Heparan Sulfate Glycan Chains, Angew. Chem. Int. Ed. 2014, 53, 9051-9058

El-dakdouki, M; Xia, J; Zhu, D. C.; Kavunja, H.; Grieshaber, J.; O'Reilly, S.; McCormick, J. J.; Huang, X.* Assessing the in Vivo Efficacy of Doxorubicin Loaded Hyaluronan Nanoparticles, ACS Appl. Mater. Interface, 2014, 6, 697–705

El-dakdouki, M.; El-boubbou, K.; Kamat, M.; Huang, R.; Abela, G.; Zhu, D. C.*; Huang, X.* CD44 Targeting Magnetic Glyconanoparticles for Atherosclerotic Plaque Imaging, Pharm Res. 2014, 31, 1426-1437 (Highlighted as front cover of the issue)

El-dakdouki, M.; El-boubbou, K.; Xia, J.; Kavunja, H.; Huang, X.* Methods for Magnetic Nanoparticle Synthesis and Functionalization Chemistry of Bioconjugates: Synthesis, Characterization, and Biomedical Applications Editor: Ravin Rarain, John Wiley & Sons, 2014, pp 281-314

2013

Wasonga, G.; Tatara, Y.; Kakizaki, I.; Huang, X.* Synthesis of N-Acetyl Glucosamine Analogs as Inhibitors for Hyaluronan Biosynthesis, J. Carbohydr. Chem. 2013, 32, 392-409

Huang, X.; Vocadlo, D. Reports from the Award Symposia Hosted by the American Chemical Society, Division of Carbohydrate Chemistry at the 245th American Chemical Society National Meeting, ACS Chem. Biol. 2013, 8, 1361-1365

Yin, J.; Comellas-Aragones, M.; Chowdhury, S.; Bentley, P.; Kaczanowska, K.; BenMohamed, L.; Gildersleeve, J. C.; Finn, M.G.; Huang, X.* Boosting Immunity to Small Tumor-Associated Carbohydrates with Bacteriophage Qβ Capsids, ACS Chem. Biol., 2013, 8, 1253-1262
This work has been highlighted by Chemical & Engineering News as well as in the June 2013 POD cast from ACS Chemical Biology

El-dakdouki, M.; Puré, E.; Huang, X.* Development of Drug Loaded Nanoparticles for Tumor Targeting. Part 2: Enhancement of Tumor Penetration Through Receptor Mediated Transcytosis in 3D Tumor Models, Nanoscale, 2013, 5, 3904-3911

El-dakdouki, M.; Puré, E.; Huang, X.* Development of Drug Loaded Nanoparticles for Tumor Targeting. Part 1: Synthesis, Characterization, and Biological Evaluation in 2D Cell Cultures, Nanoscale, 2013, 5, 3895-3903

Kouyoumdjian, H.; Zhu, D. C.; El-Dakdouki, M. H.; Lorenz, K.; Chen, J.; Li, W.; Huang, X.* Glyconanoparticle Aided Detection of β-Amyloid by Magnetic Resonance Imaging and Attenuation of β-Amyloid Induced Cytotoxicity, ACS Chem. Neurosci., 2013, 4, 575−584

2012

Yang, B.; Yoshida, K.; Yin, Z.; Dai, H.; Kavunja, H.; El-Dakdouki, M. H.; Sungsuwan, S.; Dulaney, S. B.; Huang, X.* Chemical Synthesis of Homogeneous Syndecan-1 Heparan Sulfate Glycopeptide, Angew. Chem. Int. Ed., 2012, 51, 10185-10189

Yin, Z.; Nguyen, H. G.; Chowdhury, S.; Bentley, P.; Bruckman, M. A.; Miermont, A.; Gildersleeve, J. C.; Wang, Q.; Huang, X.* Tobacco Mosaic Virus as a New Carrier for Tumor Associated Carbohydrate Antigens, Bioconjugate Chem., 2012, 23, 1694-1703. NIHMSID: 396464

Huang, X. Foreword, J. Carbohydr. Chem., 2012, 31, 253-254 Foreword to the Special Issue Dedicated to the 7th Midwest Carbohydrate and Glycobiology Symposium

Sheng, J.; Xu, Y.; Dulaney, S. B.; Huang, X.; Liu, J.* Uncovering a Biphasic Catalytic Mode of C5-epimerase in Heparan Sulfate Biosynthesis, J. Biol. Chem., 2012, 287, 20996-21002

Xu. Y.; Wang, Z.; Liu, R.; Bridges, A. S.; Huang, X.; Liu, J.* Directing the Biological Activities of Heparan Sulfate Oligosaccharides Using a Chemoenzymatic Approach, Glycobiology, 2012, 22, 96-106

Sun, B.; Yang, B.; Huang, X.* Total Synthesis of the Aminopropyl Functionalized Ganglioside GM1, Sci. China Chem., 2012, 55, 31-35

Li, H.; El-dakdouki, M.H.; Zhu, D. C.; Abela, G. S.; Huang, X.* Synthesis of b-cyclodextrin Conjugated Superparamagnetic Iron Oxide Nanoparticles for Detection of Cholesterol Crystals, Chem. Commun., 2012, 48, 3385-3387 (This article was highlighted as the back cover of the issue)

El-dakdouki, M.H.; Zhu, D. C.; El-Boubbou, K.; Kamat, M.; Chen, J.; Li, W.; Huang, X.* Development of Multifunctional Hyaluronic Acid Coated Nanoparticles: Targeted Imaging and Drug Delivery to Cancer Cells in vitro, Biomacromolecules, 2012, 13, 1144-1151

Dulaney, S. B.; Huang, X.* Recent Strategies in Heparin/heparan Sulfate Oligosaccharide Synthesis: 2000 – present, Adv. Carbohydr. Chem. Biochem., 2012, 67, 95-136 (invited review)

Yin, Z.; Huang, X.* Recent Development in Carbohydrate Based Anti-cancer Vaccines, J. Carbohydr. Chem., 2012, 31, 143-186

2011

El-dakdouki, M.H.; El-Boubbou, K.; Zhu, D. C.; Huang, X.* A Simple Method for the Synthesis of Hyaluronic Acid Coated Magnetic Nanoparticles for Highly Efficient Cell Labeling and in vivo Imaging, RSC Adv., 2011, 1, 1449-1452

Yin, Z.; Dulaney, S.; Tiruchinapally, G.; Yang, B.; Huang, X.* A Facile Method for Oxidation of Primary Alcohols to Carboxylic Acids in Carbohydrate Synthesis, Carbohydrate Chemistry, Proven Synthetic Methods, Volume 2, 2011, in press

El-dakdouki, M.H.; Huang, X.* Biological Applications of Hyaluronic Acid Functionalized Nanomaterials, in Glyco-Nanotechnology as a Bridge to New Medicines, ACS symposium series, Editors: Huang, X.; Barchi, J. 2011, 181-213

Tiruchinapally, G.; Yin, Z.; El-dakdouki, M.H.; Wang, Z.; Huang, X.* Divergent Heparin Oligosaccharide Synthesis with Pre-installed Sulfate Esters, Chem. Eur. J., 2011, 17, 10106 – 10112

El-boubbou, K.; Huang, X.* Glyco-Nanomaterials: Translating Insights from the “Sugar-code” to Biomedical Applications, Curr. Med. Chem. , 2011, 18, 2060-2078

Deng, C. X.; Huang, X.* Improved Outcome of Targeted Delivery of Chemotherapy Drug to the Brain using a Combined Strategy of Ultrasound, Magnetic Targeting, and Drug Loaded Nanoparticles, Therapeutic Delivery , 2011, 2, 137–141

Li, X.; Zhou, H.; Yang, L.; Du, G.; Pai-Panandiker, A. S.; Huang, X.; Yan, B.* Enhancement of Cell Recognition in vitro by Dual-ligand Cancer Targeting Gold Nanoparticles, Biomaterials, 2011, 232, 2540-2545

Wasonga, G.; Zeng, Y.; Huang, X.* Pre-activation Based Stereoselective Glycosylations: Stereochemical Control by Additives and Solvent, Sci. China Chem., 2011, 54, 1, 66-73

2010

Kamat, M.; El-Boubbou, K.; Zhu, D.; Lansdell, T.; Lu, X.; Li, W.; Huang, X.* Hyaluronic Acid Immobilized Magnetic Nanoparticles for Active Targeting and Imaging of Macrophages, Bioconjugate Chem., 2010, 21, 11, 2128–2135

Wang, Z.; Xu, Y.; Yang, B.; Tiruchinapally, G.; Sun, B.; Liu, R.; Dulaney, S.; Liu, J.; Huang, X.* Pre-activation-Based One-pot Combinatorial Synthesis of Heparin-like Hexasaccharides for the Analysis of Heparin–Protein Interactions, Chem. Eur. J., 2010, 16, 28, 8365-8375. (This article was rated by the reviewers as VIP publication)

El-Boubbou, K.; Zhu, D.; Vasileiou, C.; Borhan, B.; Prosperi, D.; Li, W.; Huang, X.* Magnetic Magnetic Glyco-Nanoparticles: A Tool To Detect, Differentiate, and Unlock the Glyco-Codes of Cancer via Magnetic Resonance Imaging, J. Am. Chem. Soc., 2010, 132, 12, 4490-4499.

Yang, B.; Jing, Y.; Huang, X.* Fluorous Assisted One-pot Oligosaccharide Synthesis. Eur. J. Org. Chem., 2010, 7, 1290–1298.

Wang, Y.; El-Boubbou, K.; Kouyoumdjian, H.; Sun, B.; Huang, X.; Zeng, X.* Lipoic Acid Carbohydrate Conjugates, a New Class of Agents for Controlling Nonspecific Adsorption of Blood Serum at Bio-interfaces for Biosensor and Biomedical Applications, Langmuir, 2010, 26, 4119-4125.

2009

Lu, X.; Kamat, M. N.; Huang, L.; Huang, X.* Chemical Synthesis of a Hyaluronic Acid Decasaccharide, J. Org. Chem., 2009, 74, 7608-7617 (JOC Featured article)

Li, X.; Huang, L.; Hu, X.; Huang, X.* Thio-arylglycosides with Various Aglycon Para-Substituents, a Useful Tool for Mechanistic Investigation of Chemical Glycosylations, Org. Biomol. Chem., 2009, 7, 117-127.

2008

Zeng, Y.; Wang, Z.; Whitfield, D., Huang, X.* Installation of Electron Donating Protective Groups, a Strategy for Glycosylating Unreactive Thioglycosyl Acceptors using the Pre-activation Based Glycosylation Strategy, J. Org. Chem., 2008, 73, 7952-7962.

Wang, Z.; Huang, X.* p-Toluenesulfenyl Chloride Electronic Encyclopedia of Reagents in Organic Synthesis, 2008.

Sun, B.; Srivinasan, B.; Huang, X.* Pre-activation Based One-pot Synthesis of an α-(2,3)-Sialylated Core-Fucosylated Complex Type Bi-antennary N-Glycan Dodecasaccharide, Chem. Eur. J., 2008, 14, 7072-7081

Wang, Z.; Gilbert, M.; Eguchi, H.; Yu, H.; Cheng, J.; Muthana, S.; Zhou, L.; Wang, P. G.; Chen, X.; Huang, X.* Chemoenzymatic Syntheses of Tumor-Associated Carbohydrate Antigen Globo-H and Stage-Specific Embryonic Antigen 4, Adv. Synth. Catal., 2008, 350, 1717-1728.

Miermont, A.; Barnhill, H.; Strable, E.; Lu, X.; Wall, K. A.; Wang, Q.; Finn, M. G.; Huang, X.* Cowpea Mosaic Virus Capsid, a Promising Carrier towards the Development of Carbohydrate Based Anti-tumor Vaccines, Chem. Eur. J., 2008, 14, 4939-4947.

Huang, L.; Lu, X.; Huang, X.* Chemical Syntheses of Hyaluronic Acid Oligosaccharides, in Chemical Glycobiology II: Glycopharmaceuticals and Glycovaccines, ACS symposium series, 2008.

Srinivasan, B.; Huang, X.* Functionalization of Magnetic Nanoparticles with Organic Molecules: Loading Level Determination and Evaluation of Linker Length Effect on Immobilization, Chirality , 2008, 20, 265-277. (Special issue dedicated to Prof. Nina Berova)

2007

El-Boubbou, K.; Gruden, C.; Huang, X.* Magnetic Glyco-nanoparticles: A Unique Tool for Rapid Pathogen Detection, De-contamination and Strain Differentiation, J. Am. Chem. Soc., 2007, 129, 13392-13393.

Miermont, A.; Zeng, Y.; Jing, Y.; Ye, X.-S.; Huang, X.* Syntheses of LewisX and Dimeric LewisX: Construction of Branched Oligosaccharides by a Combination of Pre-activation and Reactivity Based Chemoselective One-Pot Glycosylations, J. Org. Chem. , 2007, 72, 8958-8961.

Teumelsan, N.; Huang, X.* Synthesis of Branched Oligomannans and an Unusual Stereochemical Observation, J. Org. Chem. , 2007, 72, 8976-8979.

Wang, Z.; Zhou, L.; El-boubbou, K.; Ye, X.-S.; Huang, X.* Four Component One-Pot Synthesis of the Tumor-Associated Carbohydrate Antigen Globo-H Based on Preactivation of Thioglycoside Donors. J. Org. Chem. , 2007, 72, 6409-6420.

Wang, Z.; Huang, X.* Strategies in Oligosaccharide Synthesis in Comprehensive Glycoscience. From Chemistry to Systems Biology 2007, Editor: J. P. Kamerling, Elsevier, p379-413.

Huang, L.; Huang, X.* Highly Efficient Syntheses of Hyaluronan Oligosaccharides, Chem. Eur. J. 2007, 13, 529-540.

2006

Wang, C.; Wang, H.; Huang, X.; Zhang, L.-H.; Ye, X.-S.* Benzenesulfinyl Morpholine: A New Promoter for One-Pot Oligosaccharide Synthesis Using Thioglycosides by Pre-Activation Strategy, Synlett 2006, 2846-2850.

Huang, L.; Teumelsan, N.; Huang, X.* A Facile Method for Oxidation of Primary Alcohols to Carboxylic Acids and Its Application in Glycosaminoglycan Syntheses, Chem. Eur. J. 2006, 12, 5246-5252.

Huang, L.; Wang, Z.; Li, X.; Huang, X.* Iterative One-Pot Synthesis of Chitotetraose, Carbohydr. Res. 2006, 341, 1669-1679.

2005

Huang, L.; Huang, X.* Methyl triflate, Electronic Encyclopedia of Reagents in Organic Synthesis, 2005.

2004

Wang, Y.; Huang, X.; Zhang, L.-H.; Ye, X.-S.* A Four-Component One-Pot Synthesis of a-Gal Pentasaccharide Org. Lett. 2004, 6, 4415-4417.

Huang, X. Mercuric Bromide, Electronic Encyclopedia of Reagents in Organic Synthesis, 2004, RN00383.

Huang, X.*; Huang, L.; Wang, H.; Ye, X.-S. Iterative One-Pot Oligosaccharide Synthesis, Angew. Chem. Int. Ed. 2004, 5221-5224.

Huang, L.; Wang, Z.; Huang, X.* One-pot Oligosaccharide Synthesis: Reactivity Tuning by Post-synthetic Modification of Aglycon, Chem. Commun. 2004, 1960-1961.

Jing, Y.; Huang, X.* Fluorous Thiols in Oligosaccharide Synthesis, Tetrahedron Lett. 2004, 45, 4615-4618