Chemistry 434

On the Chemistry 434

Fall 2009

Analytical Chemistry

Course Organization, Lecture Syllabus and Other Important Information

Lectures: Monday, Wednesday, Friday 1:50 to 2:40pm

Location: Chemistry 136

Recitations: (see TA office hours below)

Required Text: D.A. Skoog, F.J. Holler and S.R. Crouch, Principles of Instrumental Analysis, 6^th Edition, Thomson Brooks/Cole Publishers, 2007.

Instructor: Professor Greg M. Swain

314 Chemistry Building

Tel. 355-9715 x229

Email: swain@chemistry.msu.edu

Instructor Office Hours: Wednesday, 12:30 to 1:30 pm, Room 314 Chemistry, or by appointment.

TA: Jiangyin Bao

baojiang@chemistry.msu.edu

Recitation Sections (Room 283): Friday, 9:10-10:00 am and 11:30-12:20 pm

Prerequisites: Chemistry 352, 392, 395

Course Objectives:

This course focuses on the theoretical and practical aspects of instrumental methods of chemical analysis. The student will develop critical thinking skills in the areas of instrument selection, method development, and data interpretation.

Exam Schedule:

September 14^th (Exam 1 – in class)

October 9^th (Exam 2 – in class)

November 2^nd (Exam 3 – in class)

November 23^rd (Exam 4 – in class)

December 16^th (Final Exam – 2 hours)

Grading:

There are a total of 1200 points available for this course:

Ten Homework sets worth 10 points each (100 points total)

Four 1-h exams worth 150 points each (600 points total)

Final Exam worth 300 points (300 points total)

Term Paper (200 points total)

Grading Scale:

The scale indicated below is based on the number of total points accrued being converted to a percentage of the total points available. These grade cut-offs are based on historical experience with this course, and they may be relaxed by a small amount, at the instructor’s discretion, based on the class exam results. In no event shall the grade levels be made more stringent than indicated below.

Raw score (1200 max)	Percentile score	Course grade
1080 – 1200	90.0 – 100%	4.0
1020 – 1079	85.0 – 89.9%	3.5
960 – 1019	80.0 – 84.9%	3.0
900 – 959	75.0 – 79.9%	2.5
840 – 899	70.0 – 74.9%	2.0
780 – 839	65.0 – 69.9%	1.5
720 – 779	60.0 – 64.9%	1.0
< 720	< 60%	0

Homework:

Homework assignments are due by the end of class on the dates indicated in the following lecture schedule. Unless other arrangements have been made in advance with the instructor, a 10% grade reduction will be given for each day late that your homework is not handed in.

Homework Keys will be posted as soon as possible after the due date (i.e., when the homework assignments have all been handed in).

Lecture Schedule:

It is assumed that the Required Reading for each week has been completed prior to the start of that weeks class.

Week	Date	Lecture Topic	Required Reading	Homework	Due
1		Introduction to Analytical Measurements and Evaluation of Analytical Data	Chapters 1 and Appendix 1	HW1 C1 – 1,7,8,9,10
	9/2 (W)
	9/4 (F)
2	9/7 (M)	No Class – Labor Day
	9/9 (W)	Signals and Noise	Chapter 5		HW1
	9/11 (F)
3	9/14 (M)	Exam 1 (subject material from weeks 1 and 2)
	9/16 (W)	Introduction to Separation Science	Chapter 26	HW2 C26 – 2,5,6,7,10
	9/18 (F)
4	9/21 (M)	Gas Chromatography	Chapter 27	Optional Problems C27-2,3,6,7,9,22
	9/23 (W)
	9/25 (F)
5	9/28 (M)	Liquid Chromatography	Chapter 28	HW3 C28 – 2-5,13,20,22	HW2
	9/30 (W)
	10/2 (F)
6	10/5 (M)	Electrophoresis	Chapter 30	HW4 C30 – 1,2,5,6,7,9	HW3
	10/7 (W)
	10/9 (F)	Exam 2 (subject material from weeks 3, 4, 5 and 6)
7	10/12 (M)	Introduction to Spectroscopy	Chapters 6 and 7	HW5 C6 – 2,3,4,7,8,9 C7 – 1,3,6,16,19	HW4
	10/14 (W)
	10/16 (F)
8	10/19 (M)	Atomic Absorption, Emission and ICP Spectroscopy	Chapters 8, 9 and 10	HW6 C8 – 2,3,6,9 C9 – 2,3,5,6,8 C10 – 2,5,6	HW5
	10/21 (W)
	10/23 (F)
9	10/26 (M)	Molecular UV-Visible Absorption and Emission Spectroscopy	Chapters 13, 14 and 15	HW7 C13 – 1,5,8,9,15 C14 – 1,2,8 C15 – 1,3,7	HW6
	10/28 (W)
	10/30 (F)
10	11/2 (M)	Exam 3 (subject material from weeks 7, 8 and 9)
	11/4 (W)	X-ray Methods of Analysis	Chapter 12	Optional Problems: 1,2,3,5
	11/6 (F)				HW7
11	11/9 (M)	Infrared Spectroscopy	Chapters 16 and 17	HW8 C16 – 1,2,4,7,8
	11/11 (W)
	11/13 (F)
12	11/16 (M)	Atomic and Molecular Mass Spectrometry	Chapters 11 and 20	HW9 C20 – 2,5,6,7,11,12,13	HW8
	11/18 (W)
	11/20 (F)
13	11/23 (M)	Exam 4 (subject material from weeks 10, 11 and 12)
	11/25 (W)	No Class Thanksgiving Holiday
	11/27 (F)
14	11/24 (M)	Introduction to Electrochemistry	Chapter 22		HW9
	11/26 (W)				HW 10
	11/28 (F)
15	12/1 (M)	Potentiometry and Voltammetry Review	Chapters 23 and 25
	12/3 (W)
	12/5 (F)
	12/11 (W)	The Final Exam will be held on Thursday, December 16 from 12:45-2:45 p.m. 50% of the exam will be based on subject material covered in weeks 13, 14 and 15, while the other 50% will cover subject material selected from the entire semester

Term Paper:

The student will select a topic covered in an A-page review article of the journal, Analytical Chemistry, within the past three years and will write a 10 page (Times Roman, 11 point, 1.5 line spacing) term paper on this topic. The term paper should have the following sections: Motivations for the Instrumental Method (what is it good for, what types of analyses are possible, and how does having the method benefit science?), Basics of the Instrument Design and Theory of Operation, Example Data and Interpretation, and Conclusions and Future Prospects. All figures are to be scanned and embedded into the text. All text used in your paper and written by another author should be cited, as appropriate. The article and topic should be discussed with the instructor ahead of time. All papers are due on or before November 10^th.

Term Paper Requirements

Religious Observances/ Other Absences from Class:

It is the responsibility of students who plan to be absent from class at certain times throughout the semester, due to religious holidays or other reasons, to make arrangements in advance with the instructor. Course notes or handouts may be obtained from the instructor if these conditions are met. If a make-up exam is required, the instructor retains the right to determine the content of the exam and the conditions of administration, giving due consideration to equitable treatment.

Academic Honesty:

Academic dishonesty at Michigan State University is defined by the General Student Regulations as conduct that violates the fundamental principles of truth, honesty, and integrity. The following conduct is specifically cited:

o Supplying or using work or answers that are not one's own.

o Providing or accepting assistance with completing assignments or examinations.

o Interfering through any means with another's academic work.

o Faking data or results.

You are expected to complete all course assignments, including homework, quizzes, tests and exams, without assistance from any source. You are expected to develop original work for this course; therefore, you may not submit course work you completed for another course to satisfy the requirements for this course. Also, you are not authorized to use the www.allmsu.com or similar web sites to complete any course work in this course.

Students who violate these rules WILL be assigned a failing grade for the course.

In cooperation with Resource Center for Persons with Disabilities, reasonable accommodation will be provided for students with disabilities. Please meet with the instructor during the first week of class to make arrangements. Alternative format print materials, large print, audio, diskette or Braille will be made available through these centers.

Thought Questions:

1. In chromatography, what is meant by a “band” and why to these bands spread?

2. Why is longitudinal diffusion a more serious problem in GC than in LC?

3. Why does plate height increase at low flow velocities?

4. What difference between packed and open tubular columns allows much longer OT columns to be used?

5. What is the difference between normal and reversed-phase LC?

6. What is the difference between isocratic and gradient elution?

7. Why does eluent strength increase in reversed-phase LC when a less polar solvent is added?

8. What is the purpose of a guard column?

9. Why does the eluent strength increase in normal-phase LC when a more polar solvent is added?

10. What is the general elution problem in LC and its solution? Same for GC?

Lecture Notes and Materials